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COMBAT SIGNED

Clearance Of Microbial Biofilms by Advancing diagnostics and Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COMBAT project word cloud

Explore the words cloud of the COMBAT project. It provides you a very rough idea of what is the project "COMBAT" about.

data    unlock    modern    wealth    national    billion    services    combat    machine    plethora    committed    learning    attempts    group    remained    infections    perspectives    strive    diagnostics    antimicrobials    unsuccessful    biofilm    gene    treatment    microbiological    context    paradigms    isolates    molecular    effectiveness    pathogenic    expression    teach    despite    decades    unprecedentedly    tools    dataset    emergence    bacterial    profiling    biology    combination    every    healthcare    basic    innovative    invisible    transform    clinical    holds    pioneer    improvements    stress    calls    chronic    genotype    domain    acute    unchanged    interference    smaller    patterns    eradicate    strategies    solutions    genomics    aeruginosa    resistance    sequence    last    patients    suffering    interpreted    science    uses    therapeutic    genome    meet    mortality    microbial    burden    association    morbidity    infection    bacteria    disease    alternative    promise    prediction    variation    pseudomonas    medical   

Project "COMBAT" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH 

Organization address
address: INHOFFENSTRASSE 7
city: BRAUNSCHWEIG
postcode: 38124
website: www.helmholtz-hzi.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙998˙750 €
 EC max contribution 1˙998˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH DE (BRAUNSCHWEIG) coordinator 1˙998˙750.00

Map

 Project objective

Every year chronic infections in patients due to biofilm formation of pathogenic bacteria are a multi-billion Euro burden to national healthcare systems. Despite improvements in technology and medical services, morbidity and mortality due to chronic infections have remained unchanged over the past decades. The emergence of a chronic infection disease burden calls for the development of modern diagnostics for biofilm resistance profiling and new therapeutic strategies to eradicate biofilm-associated infections. However, many unsuccessful attempts to address this need teach us that alternative perspectives are needed to meet the challenges. The project is committed to develop innovative diagnostics and to strive for therapeutic solutions in patients suffering from biofilm-associated infections. The objective is to apply data-driven science to unlock the potential of microbial genomics. This new approach uses tools of advanced microbiological genomics and machine learning in genome-wide association studies on an existing unprecedentedly large dataset. This dataset has been generated in my group within the last five years and comprises sequence variation and gene expression information of a plethora of clinical Pseudomonas aeruginosa isolates. The wealth of patterns and characteristics of biofilm resistance are invisible at a smaller scale and will be interpreted within context and domain-specific knowledge. The unique combination of basic molecular biology research, technology-driven approaches and data-driven science allows pioneer research dedicated to advance strategies to combat biofilm-associated infections. My approach does not only provide a prediction of biofilm resistance based on the bacteria´s genotype but also holds promise to transform treatment paradigms for the management of chronic infections and by interference with bacterial stress responses will promote the effectiveness of antimicrobials in clinical use to eradicate biofilm infections.

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The information about "COMBAT" are provided by the European Opendata Portal: CORDIS opendata.

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