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COMBAT SIGNED

Clearance Of Microbial Biofilms by Advancing diagnostics and Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COMBAT project word cloud

Explore the words cloud of the COMBAT project. It provides you a very rough idea of what is the project "COMBAT" about.

microbiological    expression    morbidity    tools    bacteria    paradigms    genomics    pathogenic    combination    association    dataset    committed    molecular    aeruginosa    acute    chronic    disease    treatment    microbial    modern    basic    patterns    isolates    diagnostics    improvements    stress    burden    billion    data    bacterial    last    pioneer    machine    unlock    strategies    infections    perspectives    pseudomonas    wealth    clinical    promise    every    suffering    effectiveness    genotype    emergence    smaller    teach    attempts    meet    strive    patients    science    services    combat    transform    calls    medical    antimicrobials    profiling    interpreted    prediction    mortality    eradicate    group    innovative    unchanged    therapeutic    infection    gene    healthcare    resistance    variation    invisible    biology    decades    interference    sequence    holds    solutions    remained    plethora    alternative    unprecedentedly    uses    despite    biofilm    genome    context    unsuccessful    learning    national    domain   

Project "COMBAT" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH 

Organization address
address: INHOFFENSTRASSE 7
city: BRAUNSCHWEIG
postcode: 38124
website: www.helmholtz-hzi.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙998˙750 €
 EC max contribution 1˙998˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH DE (BRAUNSCHWEIG) coordinator 1˙998˙750.00

Map

 Project objective

Every year chronic infections in patients due to biofilm formation of pathogenic bacteria are a multi-billion Euro burden to national healthcare systems. Despite improvements in technology and medical services, morbidity and mortality due to chronic infections have remained unchanged over the past decades. The emergence of a chronic infection disease burden calls for the development of modern diagnostics for biofilm resistance profiling and new therapeutic strategies to eradicate biofilm-associated infections. However, many unsuccessful attempts to address this need teach us that alternative perspectives are needed to meet the challenges. The project is committed to develop innovative diagnostics and to strive for therapeutic solutions in patients suffering from biofilm-associated infections. The objective is to apply data-driven science to unlock the potential of microbial genomics. This new approach uses tools of advanced microbiological genomics and machine learning in genome-wide association studies on an existing unprecedentedly large dataset. This dataset has been generated in my group within the last five years and comprises sequence variation and gene expression information of a plethora of clinical Pseudomonas aeruginosa isolates. The wealth of patterns and characteristics of biofilm resistance are invisible at a smaller scale and will be interpreted within context and domain-specific knowledge. The unique combination of basic molecular biology research, technology-driven approaches and data-driven science allows pioneer research dedicated to advance strategies to combat biofilm-associated infections. My approach does not only provide a prediction of biofilm resistance based on the bacteria´s genotype but also holds promise to transform treatment paradigms for the management of chronic infections and by interference with bacterial stress responses will promote the effectiveness of antimicrobials in clinical use to eradicate biofilm infections.

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The information about "COMBAT" are provided by the European Opendata Portal: CORDIS opendata.

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