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NanoBioMade SIGNED

Bioinorganic intracellular synthesis of photo-responsive bio-camouflaged nanomedicines

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoBioMade project word cloud

Explore the words cloud of the NanoBioMade project. It provides you a very rough idea of what is the project "NanoBioMade" about.

combine    stem    cell    de    fold    bioreactors    roles    organism    ground    little    stress    cells    biological    multiple    created    functional    loading    nanomedicines    nanoparticulate    iron    hydrodynamic    basic    100    model    profoundly    sophisticated    tools    homing    prospectively    extracellular    ingredients    unfortunately    inherit    precursors    rationally    delivered    devoted    chemical    obvious    made    bioinorganic    man    play    vesicles    degradation    physiological    strategies    progression    site    magnetic    synthesized    instance    fed    ones    proceedings    vicarious    bio    generate    living    suggested    constituents    salts    exposed    soluble    preliminary    breaking    recycle    ionic    encapsulation    inspired    synthesis    novo    communicate    nanoparticles    wi    mesenchymal    physically    exogenous    data    photothermal    cobalt    intracellular    smart    light    strategy    engineered    first    transform    innate    cancer    nano    events    tumour    natural   

Project "NanoBioMade" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙967˙000 €
 EC max contribution 1˙967˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-02-01   to  2026-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙967˙000.00

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 Project objective

Exposed to smart man-engineered nanomedicines, cells can profoundly transform and recycle them. To communicate, or in response to exogenous stress, cells generate extracellular vesicles which can play crucial roles in multiple physiological processes, as for instance, and unfortunately, for cancer progression. The goal of this proposal is to combine both biological events to deliver nanomedicines created by cells only, using mesenchymal stem cells as the most relevant cell model. The focus of this proposal on nano-bio-production is three-fold. - In the first instance, I aim to rationally develop novel strategies for bioinorganic intracellular synthesis of nanoparticles. The first aspect will be to demonstrate, as suggested by preliminary data, that nanoparticles degradation products can be de novo-synthesized nanoparticles! And also that nanoparticulate end products can also be obtained when cells are “fed” with soluble ionic salts. The vicarious synthesis using living cells as bioreactors, will allow creating functional, sophisticated and organism-friendly nanoparticles. Basic ingredients and little chemical proceedings should lead to advanced prospectively biological nano-tools. When iron and cobalt constituents will be used as precursors, cells will generate nanoparticles with magnetic and photothermal properties. - The second focus is devoted to nanoparticles biological encapsulation. Indeed, in order to be useful, nanoparticles should be efficiently delivered to the target site. In the strategy to make “100% Bio Made nanomedicines”, it is obvious there are no better delivery systems than the cell’s innate delivery systems, the extracellular vesicles, an especially the ones derived from stem cells, supposed to inherit from their natural tumour homing. Here, ground-breaking physically-inspired (hydrodynamic, light) approaches for production and loading of these vesicles with nanoparticles will be proposed and fully implemented. One specific aim wi

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