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HoliFAB SIGNED

Holistic digital-to-physical prototyping and production pilot for microfluidic MEMS

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HoliFAB project word cloud

Explore the words cloud of the HoliFAB project. It provides you a very rough idea of what is the project "HoliFAB" about.

world multiple strategy integration commercialization 1 construction requiring environment ultimate industrialization 100x active prototyping fast resolution business materials lines streamlined reagents soft connections starting moulding health quality qualified accelerate sealing printing mems innovation microfluidics lie fabrication throughput patented bio model 4th micro chips polymer flexible water prototype compatibility streamlining machines onto components first stems holistic lab recognition jointly least injection innovations helping microfluidic demonstrated instrument markets regarding limitations coordinated pilot diagnosis upscaling mass industrial lowest architectures 3 performances raw chip chain itself line revolution external single cancer organ readily inter 3d

Project "HoliFAB" data sheet

The following table provides information about the project.

Coordinator	FLUIGENT SA Organization address address: 57-77 AVENUE DE FONTAINEBLEAU city: LE KREMLIN-BICETRE postcode: 94270 website: www.fluigent.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://holifab.eu/
Total cost	9˙304˙795 €
EC max contribution	7˙152˙981 € (77%)
Programme	1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-PILOTS-2017
Funding Scheme	IA
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2020-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FLUIGENT SA FLUIGENT SA Organization address address: 57-77 AVENUE DE FONTAINEBLEAU city: LE KREMLIN-BICETRE postcode: 94270 website: www.fluigent.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE KREMLIN-BICETRE)	coordinator	1˙290˙601.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙611˙616.00
3	EV GROUP E. THALLNER GMBH EV GROUP E. THALLNER GMBH Organization address address: DI ERICH THALLNER STRASSE 1 city: ST FLORIAN AM INN postcode: 4782 website: www.evgroup.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (ST FLORIAN AM INN)	participant	888˙072.00
4	microLIQUID sl microLIQUID sl Organization address address: Av. Uribarri 19-1 city: Arrasate-Mondragon postcode: 20500 website: www.microliquid.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Arrasate-Mondragon)	participant	815˙500.00
5	SCULPTEO SCULPTEO Organization address address: 10 RUE AUGUSTE PERRET city: VILLEJUIF postcode: 94800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	606˙375.00
6	DUBLIN CITY UNIVERSITY DUBLIN CITY UNIVERSITY Organization address address: Glasnevin city: DUBLIN postcode: 9 website: www.dcu.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	520˙467.00
7	MICRO RESIST TECHNOLOGY GESELLSCHAFT FUER CHEMISCHE MATERIALIEN SPEZIELLER PHOTORESISTSYSTEME MBH MICRO RESIST TECHNOLOGY GESELLSCHAFT FUER CHEMISCHE MATERIALIEN SPEZIELLER PHOTORESISTSYSTEME MBH Organization address address: Koepenicker Strasse 325 city: BERLIN postcode: 12555 website: www.microresist.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	429˙142.00
8	T.E. LABORATORIES LIMITED T.E. LABORATORIES LIMITED Organization address address: TULLOW INDUSTRIAL ESTATE city: TULLOW postcode: R93 website: www.tellab.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (TULLOW)	participant	332˙062.00
9	MYPA INYECCION SL MYPA INYECCION SL Organization address address: CALLE A POLIGONO EL PLANO 11 city: MARIA DE HUERVA postcode: 50430 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MARIA DE HUERVA)	participant	296˙684.00
10	TECH2MARKET SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA TECH2MARKET SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA Organization address address: UL. BOHATEROW WARSZAWY 7 city: BUSKO-ZDROJ postcode: 28-100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (BUSKO-ZDROJ)	participant	200˙830.00
11	MYPA MOLDES SOCIEDAD LIMITADA MYPA MOLDES SOCIEDAD LIMITADA Organization address address: POL IND EL PLANO C A NAVE 11 city: ZARAGOZA postcode: 50171 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	participant	161˙630.00

Map

Project objective

The project aims at a holistic new design strategy, coordinated pilot lines and business model for the prototyping, fabrication and commercialization of polymer-based microfluidic systems. It stems from the recognition that a microfluidic chip is a key part of a microfluidic MEMS, but only a part. Many limitations to fast prototyping, industrialization and ultimate performances lie not in the chip itself, but in the world-to-chip connections and integration of multiple external components. We shall address in a single strategy the streamlined construction of whole microfluidic systems, starting from existing pilot lines in injection moulding, 3D printing and instrument construction. This will specific innovations. First, the resolution of 3D printing will be increased by a factor at least 10, down to 1~3µm, with a throughput 10 to 100x higher than that of current high resolution 3D printing machines, to support the flexible production of chips with complex 3D architectures. New soft, bio, environment-friendly and/or active materials will be integrated in the production chain using a technology patented by the partners. Large-scale markets requiring mass production at the lowest cost will be addressed by a fully integrated pilot line, streamlining injection moulding of raw chips, reagents and components integration, sealing and quality control. Inter-compatibility between 3D printing and injection moulding, regarding architectures and materials, will be developed to accelerate the prototype to product value chain. After development and upscaling, the technology will be demonstrated and qualified in operational environment by end-users with lab-on-chip applications in health (cancer diagnosis, organ-on chip) and environment (water control). Partners jointly have the production lines onto which the project’s innovation will be readily integrated, helping microfluidics to become a major component of the 4th industrial revolution.

Publications

List of publications.
year	authors and title	journal	last update
2018	Angelo Accardo, Marie-Charline BlatchÃ©, RÃ©mi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin Two-photon lithography and microscopy of 3D hydrogel scaffolds for neuronal cell growth published pages: 27009, ISSN: 2057-1976, DOI: 10.1088/2057-1976/aaab93	Biomedical Physics & Engineering Express 4/2	2019-12-16
2019	Justine Creff, RÃ©mi Courson, Thomas Mangeat, Julie Foncy, Sandrine Souleille, C. Thibault, Arnaud Besson, Laurent Malaquin Fabrication of 3D scaffolds reproducing intestinal epithelium topography by high-resolution 3D stereolithography published pages: 119404, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119404	Biomaterials 221	2019-12-16
2018	Petra Juskova, Alexis Ollitrault, Marco Serra, Jean-Louis Viovy, Laurent Malaquin Resolution improvement of 3D stereo-lithography through the direct laser trajectory programming: Application to microfluidic deterministic lateral displacement device published pages: 239-247, ISSN: 0003-2670, DOI: 10.1016/j.aca.2017.11.062	Analytica Chimica Acta 1000	2019-12-16
2018	Andrew Donohoe, Gareth Lacour, Peter McCluskey, Dermot Diamond, Margaret McCaul Development of a Cost-Effective Sensing Platform for Monitoring Phosphate in Natural Waters published pages: 57, ISSN: 2227-9040, DOI: 10.3390/chemosensors6040057	Chemosensors 6/4	2019-10-30
2018	Angelo Accardo, RÃ©mi Courson, Roberto Riesco, Vincent Raimbault, Laurent Malaquin Direct laser fabrication of meso-scale 2D and 3D architectures with micrometric feature resolution published pages: 440-446, ISSN: 2214-8604, DOI: 10.1016/j.addma.2018.04.027	Additive Manufacturing 22	2019-10-30
2018	Eoin Murray, Yan Li, Sinead A. Currivan, Breda Moore, Aoife Morrin, Dermot Diamond, Mirek Macka, Brett Paull Miniaturized capillary ion chromatograph with UV light-emitting diode based indirect absorbance detection for anion analysis in potable and environmental waters published pages: 3224-3231, ISSN: 1615-9306, DOI: 10.1002/jssc.201800495	Journal of Separation Science 41/16	2019-10-30
2019	Roberto Riesco, Louisa Boyer, Sarah Blosse, Pauline M. Lefebvre, Pauline Assemat, Thierry LeichlÃ©, Angelo Accardo, Laurent Malaquin Water-in-PDMS emulsion templating of highly interconnected porous architectures for 3D cell culture published pages: , ISSN: 1944-8244, DOI: 10.1021/acsami.9b07564	ACS Applied Materials & Interfaces	2019-10-30
2018	Angelo Accardo, Marie-Charline BlatchÃ©, RÃ©mi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin Direct laser fabrication of free-standing PEGDA-hydrogel scaffolds for neuronal cell growth published pages: 315-316, ISSN: 1369-7021, DOI: 10.1016/j.mattod.2018.02.004	Materials Today 21/3	2019-10-30

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