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mRNP-PackArt SIGNED

Nuclear mRNA Packaging and mRNP Architecture

Total Cost €

EC-Contrib. €

Partnership

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mRNP-PackArt project word cloud

Explore the words cloud of the mRNP-PackArt project. It provides you a very rough idea of what is the project "mRNP-PackArt" about.

export insights combining messenger cerevisiae defects synthesized nuclear rna stability mrnp powerful poorly structural expression despite summary mass organism mrna processed polymerase posttranscriptional time contain rnp purify coding quantify cellular elucidate bound architecture polyadenylated structure protein microscopy transcribing illuminate mrnps particle packaged model ribonucleoprotein cytoplasmic electron molecular nature dynamic purification decay rbps packaging localization capped ground an disease biochemistry gene spectrometry fundamental biogenesis linking composition spliced binding cross mrnas break first mechanism proteins fact mechanistic stages strategies translation

Project "mRNP-PackArt" data sheet

The following table provides information about the project.

Coordinator	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN Organization address address: LUDWIGSTRASSE 23 city: GIESSEN postcode: 35390 website: www.uni-giessen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙991˙387 €
EC max contribution	1˙991˙387 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2023-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN JUSTUS-LIEBIG-UNIVERSITAET GIESSEN Organization address address: LUDWIGSTRASSE 23 city: GIESSEN postcode: 35390 website: www.uni-giessen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GIESSEN)	coordinator	1˙991˙387.00

Map

Project objective

An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP). The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene. The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs). The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localization, translation and decay. Thus, the formation and composition of an mRNP is important for the posttranscriptional control of gene expression. Despite its essential nature, the mechanism of nuclear mRNP packaging and the architecture of an mRNP are still poorly understood due to the fact that mRNPs contain many different mRNAs. The overall goal of this proposal is to elucidate the mechanism of mRNP formation and the molecular structure of an mRNP. Specifically, In aim 1, we will determine and quantify the protein composition of a specific mRNP including different stages during its biogenesis; In aim 2, we will illuminate the molecular mechanism of mRNP packaging; and In aim 3, we will elucidate the architecture of an mRNP by cross-linking mass spectrometry and electron microscopy. These aims will be achieved by combining novel RNP purification strategies and the powerful biochemistry of the model organism S. cerevisiae to purify a specific mRNP with recent advances in high-end mass spectrometry and electron microscopy. In summary, the expected results of this project will show the architecture of an mRNP in its dynamic nature. mRNP packaging will be understood for the first time on a mechanistic as well as structural level. Thus, the results of this project will break new ground in our understanding of this fundamental cellular process and will also provide insights into how defects in this process lead to disease.

Deliverables

List of deliverables.
Research Data	Open Research Data Pilot	2019-10-01 09:18:44

Take a look to the deliverables list in detail: detailed list of mRNP-PackArt deliverables.

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