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SynarchiC SIGNED

Investigating the functional architecture of microbial genomes with synthetic approaches

Total Cost €

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EC-Contrib. €

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Partnership

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 SynarchiC project word cloud

Explore the words cloud of the SynarchiC project. It provides you a very rough idea of what is the project "SynarchiC" about.

track    conserved    hosts    gene    actively    consists    fundamental    involve    insights    genomes    ing    contacts    folded    cycle    functionally    synarchic    innovative    ranging    environment    host    combined    yeast    expression    difficult    maintenance    players    capture    entire    regulates    infectious    organization    networks    scientists    bacteria    clade    chromosomes    discriminate    functional    assortment    unable    chromosome    metabolism    microbial    structures    eukaryotic    smc    conformation    prokaryotic    folding    layers    reverse    broadly    phylum    limiting    intermingled    chromatids    sister    scs    synthetic    patterns    topological    redirects    technologies    dynamic    3d    mitosis    genome    evolutionary    metabolic    structural    intertwined    sc    engineering    molecules    uncovered    replication    derivatives    interplay    pathogen    individualization    molecular    appeal    disambiguating    multiple    characterization    interacts    cell    limited    segregation    perspective    proteins    duplicated    stressful   

Project "SynarchiC" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country France [FR]
 Total cost 1˙995˙557 €
 EC max contribution 1˙995˙557 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙995˙557.00

Map

 Project objective

The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features. The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from gene expression to chromosome segregation. Some higher order structures involve evolutionary conserved molecular players, such as structural maintenance of chromosomes (SMC) proteins, while others depend on phylum specific proteins. The functional organization of yeast and bacteria chromosomes are actively investigated, with multiple folded structures uncovered in recent years. However, disambiguating the intermingled structures is a difficult task, limiting their functional characterization. In addition, current technologies are limited and are unable to track the genome-wide folding of duplicated sister chromatids (SC) molecules, limiting the study of genome folding during replication and mitosis.

The overall aim of the SynarchiC project is to characterize, through innovative derivatives of the chromosome conformation capture technology combined with synthetic chromosomes, the folding patterns of microbial genomes during the entire cell cycle, including those of SCs. By reverse engineering chromosomes in bacteria and yeast, we will discriminate the different layers of topological structures and their associated molecular players. We will then investigate how these 3D structures affect SC folding, individualization, and segregation. Finally, we will investigate the interplay between a pathogen and its hosts during an infectious process. How the bacteria redirects its host chromosome metabolism in stressful environment will be addressed from the perspective of genome organization and segregation. Technologies and results from SynarchiC will provide fundamental insights on the cell cycle, and should appeal broadly to scientists working on various aspects genome functional organization in any clade.

 Publications

year authors and title journal last update
List of publications.
2018 Héloïse Muller, Vittore F Scolari, Nicolas Agier, Aurèle Piazza, Agnès Thierry, Guillaume Mercy, Stéphane Descorps‐Declere, Luciana Lazar‐Stefanita, Olivier Espeli, Bertrand Llorente, Gilles Fischer, Julien Mozziconacci, Romain Koszul
Characterizing meiotic chromosomes\' structure and pairing using a designer sequence optimized for Hi‐C
published pages: , ISSN: 1744-4292, DOI: 10.15252/msb.20188293 		Molecular Systems Biology 14/7 2019-12-17

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The information about "SYNARCHIC" are provided by the European Opendata Portal: CORDIS opendata.

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