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UTERUS SIGNED

Unravelling gamma delta T cell emergence and responses in the uterus

Total Cost €

EC-Contrib. €

Partnership

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UTERUS project word cloud

Explore the words cloud of the UTERUS project. It provides you a very rough idea of what is the project "UTERUS" about.

hindering pathogens inflammatory repair tumorigenic limiting btnl blood intestinal 17a promotion places reveal location populations ontogeny epithelial proportion infection damage gamma invariant protection barrier least cytokine activation gd17 cellular thought infections sites fungal conserved close butyrophilin bear humans standpoint epidermal pro exacerbation receptor immune intraepithelial uterine termed tissues cells drug pathogenic tract fracture btnls bacterial small shown requirement female driving central reside expressed thereby alterations homing guiding insult body transformation play constitute niches direct effect enriched arguably secreting cues lymphocytes promptly proteins cell clinical reproductive tissue gd contact functional embryonic basic molecules precommitted il position delta

Project "UTERUS" data sheet

The following table provides information about the project.

Coordinator	THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

Gamma delta (gd) T cells constitute a small proportion of blood lymphocytes, but are enriched at barrier sites, where they reside in close contact with epithelial cells. Their location at sites of pathogenic insult and cellular transformation, together with their ability to promptly respond to tissue alterations, places them in a central position in immune protection. We have shown that epithelial molecules direct the development of tissue-specific populations of gd T cells. Indeed, we have identified a role for epithelial-expressed butyrophilin-like (Btnl) proteins in driving the development of epidermal and intraepithelial gd T cells. Importantly, the requirement for Btnls is conserved in intestinal gd T cells in humans. In this project, we will focus on uterine gd T cells, which are arguably one of the least understood populations of gd T cells. These cells bear a specific, invariant T cell receptor, and are thought to become precommitted to an IL-17A-secreting programme during early ontogeny. In other tissues, these cells, termed gd17, can rapidly produce the pro-inflammatory cytokine IL-17A following infection, thereby contributing to limiting infection with bacterial and fungal pathogens. In addition, gd17 cells have been shown to play a role in tissue repair, including promotion of fracture repair. However, the inflammatory effects of IL-17A can also lead to exacerbation of tissue damage and to a pro-tumorigenic effect. In this project, we will determine the functional characteristics of uterine gd T cells, and identify novel factors guiding the development and homing of these cells. Understanding the cues driving gd T cell development and activation at specific body niches is not only essential from a basic research standpoint, but may reveal novel drug targets for various clinical conditions, particularly in the face of emerging infections targeting the female reproductive tract and hindering embryonic development.

Publications

List of publications.
year	authors and title	journal	last update
2019	Leticia Monin, Emily M. Whettlock, Victoria Male Immune responses in the human female reproductive tract published pages: , ISSN: 0019-2805, DOI: 10.1111/imm.13136	Immunology	2020-04-24

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