Explore the words cloud of the ImmunAID project. It provides you a very rough idea of what is the project "ImmunAID" about.
The following table provides information about the project.
Coordinator |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Organization address contact info |
Coordinator Country | France [FR] |
Total cost | 15˙835˙851 € |
EC max contribution | 15˙835˙851 € (100%) |
Programme |
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease) |
Code Call | H2020-SC1-2017-Single-Stage-RTD |
Funding Scheme | RIA |
Starting year | 2018 |
Duration (year-month-day) | from 2018-05-01 to 2023-04-30 |
Take a look of project's partnership.
Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.
year | authors and title | journal | last update |
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2019 |
Flora Magnotti, Lucie Lefeuvre, Sarah Benezech, Tiphaine Malsot, Louis Waeckel, Amandine Martin, Sébastien Kerever, Daria Chirita, Marine Desjonqueres, Agnès Duquesne, Mathieu Gerfaudâ€Valentin, Audrey Laurent, Pascal Sève, Michelâ€Robert Popoff, Thierry Walzer, Alexandre Belot, Yvan Jamilloux, Thomas Henry Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201910547 |
EMBO Molecular Medicine 11/11 | 2020-04-11 |
2019 |
Emely Verweyen, Dirk Holzinger, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Peter Pickkers, Sabrin Albeituni, Katherine Verbist, Kim E Nichols, Grant Schulert, Alexei Grom, Dirk Foell, Christoph Kessel Synergistic TLR/IFNα/β-Signaling Facilitates Escape of IL-18 Expression from Endotoxin Tolerance published pages: , ISSN: 1073-449X, DOI: 10.1164/rccm.201903-0659oc |
American Journal of Respiratory and Critical Care Medicine | 2020-04-11 |
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The information about "IMMUNAID" are provided by the European Opendata Portal: CORDIS opendata.