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NucleolusChromatin SIGNED

Analysis of the nucleolus in genome organization and function

Total Cost €

EC-Contrib. €

Partnership

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NucleolusChromatin project word cloud

Explore the words cloud of the NucleolusChromatin project. It provides you a very rough idea of what is the project "NucleolusChromatin" about.

chromatin associating elucidation insights cells fill understand cellular nads differentiate inhibitory basal organization moving is expression undergo architecture elusive located landmarks regulates molecular spatial obtain nuclear mechanisms repressive chromosomes structural transcription nucleolar toward map nucleolus genome obtainment function periphery genes types functions cell diverse gap np interaction programs genomes physiological principles indicated instance gene remained eukaryotic regulation folding basic correct pathological poorly specialized subcompartments domains chromosome functionally contribution organizational thought issue compartmentalization locating functional either stimulatory documented biology lads

Project "NucleolusChromatin" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: Zürich postcode: 8006 website: http://www.unizh.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	2˙500˙000 €
EC max contribution	2˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2023-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: Zürich postcode: 8006 website: http://www.unizh.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Zürich)	coordinator	2˙500˙000.00

Map

Project objective

In eukaryotic cells, the higher-order organization of genomes is functionally important to ensure correct execution of gene expression programs. For instance, as cells differentiate into specialized cell types, chromosomes undergo diverse structural and organizational changes that affect gene expression and other cellular functions. However, how this process is achieved is still poorly understood. The elucidation of the mechanisms that control the spatial architecture of the genome and its contribution to gene regulation is a key open issue in molecular biology, relevant for physiological and pathological processes. Increasing evidence indicated that large-scale folding of chromatin may affect gene expression by locating genes to specific nuclear subcompartments that are either stimulatory or inhibitory to transcription. Nuclear periphery (NP) and nucleolus are two important nuclear landmarks where repressive chromatin domains are often located. The interaction of chromosomes with NP and nucleolus is thought to contribute to a basal chromosome architecture and genome function. However, while the role of NP in genome organization has been well documented, the function of the nucleolus remains yet elusive. To fully understand how genome organization regulates chromatin and gene expression states, it is necessary to obtain a comprehensive functional map of genome compartmentalization. However, so far, only domains associating with NP (LADs) have been identified and characterized while nucleolar-associated domains (NADs) remained under-investigated. The aim of this project is to fill this gap by developing methods to identify and characterize NADs and analyse the role of the nucleolus in genome organization, moving toward the obtainment of a comprehensive functional map of genome compartmentalization for each cell state and providing novel insights into basic principles of genome organization and its role in gene expression and cell function that yet remain elusive.

Publications

List of publications.
year	authors and title	journal	last update
2019	Jelena Kresoja-Rakic, Raffaella Santoro Nucleolus and rRNA Gene Chromatin in Early Embryo Development published pages: 868-879, ISSN: 0168-9525, DOI: 10.1016/j.tig.2019.06.005	Trends in Genetics 35/11	2019-12-16
2019	Cristiana Bersaglieri, Raffaella Santoro Genome Organization in and around the Nucleolus published pages: 579, ISSN: 2073-4409, DOI: 10.3390/cells8060579	Cells 8/6	2019-12-16

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