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MRI COMIQSUM SIGNED

MRI COntrast using MIcrobubbles in Quantitative SUsceptibility Mapping

Total Cost €

EC-Contrib. €

Partnership

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MRI COMIQSUM project word cloud

Explore the words cloud of the MRI COMIQSUM project. It provides you a very rough idea of what is the project "MRI COMIQSUM" about.

mr dual diagnostic quantify engineering applicability difficult artifacts prof supervision me drug concentrations clinical structures signal share gene microbubbles tailor monitoring academic instead expert image treating leader bright quantitative antibody promises fellowship mapping standard springboard uterine physicist fibroids maps anatomical qsm detect mentorship differentiate therapeutic ultrasound agent create eleanor susceptibility dr collaborating training shmueli contrast distinguishable resonance skills sources guided detecting magnetic guidance noise modality surgery decrease mediated imaging spectrum therapies images qualitatively expertise agents industrial ratio metastases group mri concentration microbubble bone enhanced magnitude karin uses internationally drop stride

Project "MRI COMIQSUM" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2021-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

Microbubbles are an established ultrasound contrast agent; detecting them with Magnetic Resonance Imaging (MRI) would open up a wide spectrum of dual-modality applications such as MR-guided focused ultrasound therapies. So far, MRI has been used to qualitatively assess the concentration of microbubbles based on a decrease in the MRI signal magnitude, which is difficult to differentiate from other sources of signal drop-out. In this fellowship, I will exploit quantitative susceptibility mapping (QSM), a novel approach, to detect microbubbles using MRI. QSM uses the phase, instead of the magnitude, of the complex MRI signal, which promises to enhance MRI of microbubbles because phase images have higher contrast-to-noise ratio than standard magnitude images. With the supervision and mentorship of Dr Karin Shmueli, an MRI physicist and internationally recognized expert in QSM, I will investigate the ability of QSM to quantify microbubble concentrations. Collaborating with Prof. Eleanor Stride, a leader in microbubble engineering, I will tailor the susceptibility of microbubbles for different clinical applications so that microbubbles will create bright contrast in susceptibility maps, clearly distinguishable from anatomical structures and image artifacts. This project will enhance the clinical applicability of microbubbles as a dual-modality, MRI and ultrasound, contrast agent. QSM of microbubbles has the potential to improve MRI guidance and monitoring of microbubble-mediated drug, antibody or gene delivery as well as microbubble-enhanced focused ultrasound surgery, which is currently in use for treating uterine fibroids and bone metastases. This fellowship will be a springboard towards widespread diagnostic and therapeutic applications of QSM of microbubbles. The unique training and skills provided by the fellowship will help me to establish my own research group and share the expertise I build in QSM and contrast agents with academic and industrial partners.

Publications

List of publications.
year	authors and title	journal	last update
2019	Barbara Dymerska, Pedro De Lima Cardoso, Beata Bachrata, Florian Fischmeister, Eva Matt, Roland Beisteiner, Siegfried Trattnig, Simon Daniel Robinson The Impact of Echo Time Shifts and Temporal Signal Fluctuations on BOLD Sensitivity in Presurgical Planning at 7 T published pages: 1, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000546	Investigative Radiology	2020-03-06

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The information about "MRI COMIQSUM" are provided by the European Opendata Portal: CORDIS opendata.