Explore the words cloud of the M-Lysosomes project. It provides you a very rough idea of what is the project "M-Lysosomes" about.
The following table provides information about the project.
Coordinator |
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Organization address contact info |
Coordinator Country | Spain [ES] |
Total cost | 170˙121 € |
EC max contribution | 170˙121 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2017 |
Funding Scheme | MSCA-IF-EF-RI |
Starting year | 2019 |
Duration (year-month-day) | from 2019-01-02 to 2021-01-01 |
Take a look of project's partnership.
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1 | FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE | ES (L'HOSPITALET DE LLOBREGAT) | coordinator | 170˙121.00 |
Controlling cell cycle, process by which cells progress and divide, is at the heart of cancer research therapies. Tumor cells signature often lays in high proliferation rate, alterations of multiple intracellular signaling networks and hijacking of programmed-cell death pathways. Implication of autophagy and lysosomal biology in cancer is still controversial. Lysosomes are catabolic vesicles involved in the degradation of biological material and need to be tightly regulated. Lysosomes may influence cancer formation and progression by regulating many complex processes of cell biology, such as cell signaling, cell death, nutrient sensing and cell metabolism. Lysosome function depends on lysosome acidification capacity modulated by proton pump v-ATPase activity and on its intracellular localization driven by motor proteins, mainly by motor protein kinesin KIF5B. We recently discover an innovative mechanism involving lysosomes impairment to induce mitotic error that could potentially lead tumor cells to cell death.
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The information about "M-LYSOSOMES" are provided by the European Opendata Portal: CORDIS opendata.