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SafePack SIGNED

Assessing safety of food packaging through computational toxicology

Total Cost €

EC-Contrib. €

Partnership

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SafePack project word cloud

Explore the words cloud of the SafePack project. It provides you a very rough idea of what is the project "SafePack" about.

packaging safety predictive screened toxic usable covered lack ready predicted animal determines balancing compare alarm endpoints identification developmental thousands estimates dose foods toxicities poisons fill hazard obtain created predict moe powerful endocrine suitable alert margins moes strategy bisphenol carcinogenic workflow qualitative publicly size documented free models potency compiled health computational migrate toxicology risk risks toxicity screen quantitative chemicals toxicological platform vega data contained effect food standard mutagenicity tools characterization potentially silico chronic gaps safepack predictions exposure mainly sequentially

Project "SafePack" data sheet

The following table provides information about the project.

Coordinator	NESTEC SA Organization address address: AVENUE NESTLE 55 city: VEVEY postcode: 1800 website: www.nestle.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	175˙419 €
EC max contribution	175˙419 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-SE
Starting year	2018
Duration (year-month-day)	from 2018-03-16 to 2020-08-19

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NESTEC SA NESTEC SA Organization address address: AVENUE NESTLE 55 city: VEVEY postcode: 1800 website: www.nestle.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (VEVEY)	coordinator	175˙419.00

Map

Project objective

'Thousands of chemicals contained in food packaging may potentially migrate into foods and result in consumer exposure. There is an increasing alarm about their potential toxicological effects since most of them lack data, while others (e.g. bisphenol A) have created significant debate because of their documented endocrine properties. This project, SafePack, aims to offer a publicly usable in silico strategy to establish rapidly and cost-efficiently the level of safety concern of packaging chemicals without animal toxicity testing. There has been already initiatives to screen packaging chemicals using in silico toxicology, but all of them use qualitative approaches, mainly mutagenicity predictions, suitable for hazard identification. However they do not provide information about hazard characterization (how much is needed for triggering a toxic effect) and even less about health risks. In toxicology, 'the dose makes the poisons' and it is very important to address safety concern by balancing predicted toxicological alert with potential exposure as done in standard risk assessment. The SafePack project aims at a) fill the toxicological data gaps of large sets of packaging chemicals using computational tools to predict toxicities, b) compare predicted toxicological values with exposure to obtain Margins of Exposure (MoE), a powerful method to establish level of safety concern, c) implement the overall workflow in freely available VEGA platform to make it ready for free utilization. Thousands packaging chemicals will be compiled. A number of toxicity endpoints relevant for risk assessment will be sequentially screened using available in silico predictive models: mutagenicity, carcinogenic potency and chronic toxicity; also, endocrine activity and developmental toxicity will be covered. The quantitative predicted values will be compared to exposure estimates providing MoEs, the size of which determines the level of safety concern.'

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The information about "SAFEPACK" are provided by the European Opendata Portal: CORDIS opendata.