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RiboLife SIGNED

Resurrecting LUCA - Engineering of RNA-encoded Cellular Life Using Dual Evolution and Intergenomic Transplantation

Total Cost €

0

EC-Contrib. €

0

Partnership

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 RiboLife project word cloud

Explore the words cloud of the RiboLife project. It provides you a very rough idea of what is the project "RiboLife" about.

questions    free    ancient    create    genetic    crispr    ancestor    genomes    molecular    luca    evolve    intracellular    transplantation    depends    rounds    complementation    history    answer    day    central    refine    assisted    driver    stored    world    recreating    rna    primitive    existence    core    cas9    body    prototype    doppelganger    infers    explore    combined    transformative    alternating    synthetic    intergenomic    dual    life    biological    alternative    shape    cell    modern    transfer    last    iterative    dna    universal    genomic    functions    chromosomes    living    entities    darwinian    experimentally    extremely    evolution    strategy    precursors    genome    fundamentally    replication    engineering    reengineering    strictly    encoding    biology    construct    material    networks    environments    encoded    team    editing    made    survive    bacterial    representing    replicons    transition    positively    deletion    combining    cellular    fossil    hybrids   

Project "RiboLife" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙500˙000.00

Map

 Project objective

Modern cellular life strictly depends on DNA as genetic material. However, a large body of evidence infers the existence of a previous, more primitive biology in which RNA also stored information in cellular entities. Recreating a living cellular fossil representing this transition from an ancient RNA world to modern DNA-based life would fundamentally advance our understanding of our biology’s history, and enable us to explore its biological properties experimentally. However, the reengineering of existing molecular systems into a viable doppelganger of the Last Universal Common Ancestor (LUCA) or one of its precursors is extremely challenging. I propose to use a novel, combined top-down and bottom-up approach to create a modern-day doppelganger of LUCA by engineering bacterial hybrids with core cellular functions encoded on RNA. Using Darwinian Evolution as driver, my team and I will prototype and refine synthetic RNA-replicons through alternating replication in both cell-free and intracellular environments. This “dual evolution” approach will shape increasingly complex RNA networks capable of encoding complex genetic information. Following this, we will use these networks to create information-rich RNA chromosomes, enabling the transfer of essential genomic information from DNA to RNA. Finally, we will address this intergenomic transplantation by combining a novel RNA-delivery strategy with iterative rounds of genome deletion and complementation using state-of-the art CRISPR-Cas9 assisted genome editing.

The proposed research will fundamentally advance synthetic biology, and could positively answer the transformative questions: Can we create, program and evolve life-like systems that can survive in both cell-free and intracellular environments? Can we use these entities to construct an alternative biology in which central cellular activities are encoded on genomes not made of DNA?

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The information about "RIBOLIFE" are provided by the European Opendata Portal: CORDIS opendata.

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