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RiboLife SIGNED

Resurrecting LUCA - Engineering of RNA-encoded Cellular Life Using Dual Evolution and Intergenomic Transplantation

Total Cost €

0

EC-Contrib. €

0

Partnership

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 RiboLife project word cloud

Explore the words cloud of the RiboLife project. It provides you a very rough idea of what is the project "RiboLife" about.

alternating    survive    genome    modern    explore    molecular    refine    team    stored    darwinian    day    material    cas9    entities    combined    representing    crispr    intracellular    world    strategy    core    shape    existence    combining    body    chromosomes    central    reengineering    encoded    last    primitive    transformative    editing    questions    construct    environments    precursors    biological    transfer    deletion    history    ancient    engineering    universal    evolve    synthetic    hybrids    fossil    alternative    luca    transplantation    replication    dna    recreating    infers    create    doppelganger    made    cellular    iterative    rna    strictly    bacterial    networks    fundamentally    dual    answer    life    genomes    complementation    rounds    depends    driver    assisted    prototype    experimentally    free    biology    cell    genetic    extremely    living    intergenomic    replicons    genomic    evolution    positively    encoding    ancestor    functions    transition   

Project "RiboLife" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙500˙000.00

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 Project objective

Modern cellular life strictly depends on DNA as genetic material. However, a large body of evidence infers the existence of a previous, more primitive biology in which RNA also stored information in cellular entities. Recreating a living cellular fossil representing this transition from an ancient RNA world to modern DNA-based life would fundamentally advance our understanding of our biology’s history, and enable us to explore its biological properties experimentally. However, the reengineering of existing molecular systems into a viable doppelganger of the Last Universal Common Ancestor (LUCA) or one of its precursors is extremely challenging. I propose to use a novel, combined top-down and bottom-up approach to create a modern-day doppelganger of LUCA by engineering bacterial hybrids with core cellular functions encoded on RNA. Using Darwinian Evolution as driver, my team and I will prototype and refine synthetic RNA-replicons through alternating replication in both cell-free and intracellular environments. This “dual evolution” approach will shape increasingly complex RNA networks capable of encoding complex genetic information. Following this, we will use these networks to create information-rich RNA chromosomes, enabling the transfer of essential genomic information from DNA to RNA. Finally, we will address this intergenomic transplantation by combining a novel RNA-delivery strategy with iterative rounds of genome deletion and complementation using state-of-the art CRISPR-Cas9 assisted genome editing.

The proposed research will fundamentally advance synthetic biology, and could positively answer the transformative questions: Can we create, program and evolve life-like systems that can survive in both cell-free and intracellular environments? Can we use these entities to construct an alternative biology in which central cellular activities are encoded on genomes not made of DNA?

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The information about "RIBOLIFE" are provided by the European Opendata Portal: CORDIS opendata.

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