Explore the words cloud of the AIMS-2-TRIALS project. It provides you a very rough idea of what is the project "AIMS-2-TRIALS" about.
The following table provides information about the project.
Coordinator |
KING'S COLLEGE LONDON
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | https://www.aims-2-trials.eu/ |
Total cost | 113˙274˙914 € |
EC max contribution | 54˙999˙998 € (49%) |
Programme |
1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2)) |
Code Call | H2020-JTI-IMI2-2016-10-two-stage |
Funding Scheme | IMI2-RIA |
Starting year | 2018 |
Duration (year-month-day) | from 2018-06-01 to 2023-05-31 |
Take a look of project's partnership.
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition affecting over five million people in the European Union. The combination of core symptoms (deficits in social-communication and repetitive and restricted behaviours and interests) and common comorbidities (e.g. epilepsy and depression) significantly reduces the quality of life and life-span of affected individuals. Currently there are no effective drug treatments for the core symptoms. Key factors that have hampered progress include; 1) limited understanding of the underlying pathophysiolog(ies); 2) lack of successful translation from animal models to humans; 3) testing of drugs with specific actions in biologically heterogeneous populations; 4) limited expertise of many European ASD centres in running large-scale clinical trials; and 5) trial designs (e.g. placebo effects).
Our vision, therefore, is to apply a precision medicine approach to ASD and improve patient outcomes by tailoring treatments to a patient’s biological profile. Our efforts will build on the achievements of 5 other IMI initiatives, 4 Horizon 2020 networks, and 6 SMEs for the first time to; 1) align global resources to validate and qualify stratification biomarkers from infancy to adulthood; 2) develop objective outcome measures that can be used in trials; 3) create a European-wide clinical trials network that reliably carries out studies able to support filings to the EMA/FDA; 4) carry out better targeted clinical trials linked to other international efforts – including quick wins or “fast fails” of ineffective agents; 5) translate molecular mechanisms and drug effects between preclinical models and particular subtypes of ASD.
Together we will bring Europe to the forefront of clinical research in ASD. Also we will provide a sustainable legacy that is accessible by others across the world, attracts industry into ASD, and helps transform healthcare.
First report of Engagement, Dissemination and Communication Plan | Websites, patent fillings, videos etc. | 2020-04-16 12:28:43 |
Press Release | Websites, patent fillings, videos etc. | 2020-04-16 12:28:42 |
AIMS-2-TRIALS Website launched | Websites, patent fillings, videos etc. | 2020-04-16 12:28:42 |
Draft of Data Management plan | Open Research Data Pilot | 2020-04-16 12:28:42 |
SOPs finalised and e-data management systems established | Documents, reports | 2020-04-16 12:28:42 |
Clinical Trial Network (CTN) established and trained to GCP standards and ‘trial ready’ with a single point of contact | Documents, reports | 2020-04-16 12:28:42 |
Take a look to the deliverables list in detail: detailed list of AIMS-2-TRIALS deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Inês Pote, Siying Wang, Vaheshta Sethna, Anna Blasi, Eileen Daly, Maria Kuklisovaâ€Murgasova, Sarah Lloydâ€Fox, Evelyne Mercure, Paula Busuulwa, Vladimira Stoencheva, Tony Charman, Steven C. R. Williams, Mark H. Johnson, Declan G. M. Murphy, Grainne M. McAlonan Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood published pages: 614-627, ISSN: 1939-3806, DOI: 10.1002/aur.2083 |
Autism Research 12/4 | 2020-04-16 |
2019 |
Charlotte Marie Pretzsch, Jan Freyberg, Bogdan Voinescu, David Lythgoe, Jamie Horder, Maria Andreina Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Richard A. E. Edden, Steven Williams, Declan G. M. Murphy, Eileen Daly, Gráinne M. McAlonan Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder published pages: 1398-1405, ISSN: 0893-133X, DOI: 10.1038/s41386-019-0333-8 |
Neuropsychopharmacology 44/8 | 2020-04-16 |
2019 |
Thomas Wolfers, Dorothea L. Floris, Richard Dinga, Daan van Rooij, Christina Isakoglou, Seyed Mostafa Kia, Mariam Zabihi, Alberto Llera, Rajanikanth Chowdanayaka, Vinod J. Kumar, Han Peng, Charles Laidi, Dafnis Batalle, Ralica Dimitrova, Tony Charman, Eva Loth, Meng-Chuan Lai, Emily Jones, Sarah Baumeister, Carolin Moessnang, Tobias Banaschewski, Christine Ecker, Guillaume Dumas, Jonathan O’Muir From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder published pages: 240-254, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2019.07.010 |
Neuroscience & Biobehavioral Reviews 104 | 2020-04-16 |
2019 |
Pär Nyström, Emilia Thorup, Sven Bölte, Terje Falck-Ytter Joint Attention in Infancy and the Emergence of Autism published pages: 631-638, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.05.006 |
Biological Psychiatry 86/8 | 2020-04-16 |
2019 |
E.J.H. Jones, L. Mason, J. Begum Ali, C. van den Boomen, R. Braukmann, E. Cauvet, E. Demurie, R.S. Hessels, E.K. Ward, S. Hunnius, S. Bolte, P. Tomalski, C. Kemner, P. Warreyn, H. Roeyers, J. Buitelaar, T. Falck-Ytter, T. Charman, M.H. Johnson Eurosibs: Towards robust measurement of infant neurocognitive predictors of autism across Europe published pages: 101316, ISSN: 0163-6383, DOI: 10.1016/j.infbeh.2019.03.007 |
Infant Behavior and Development 57 | 2020-04-16 |
2018 |
Jamie Horder, Max Andersson, Maria A. Mendez, Nisha Singh, Ämma Tangen, Johan Lundberg, Antony Gee, Christer Halldin, Mattia Veronese, Sven Bölte, Lars Farde, Teresa Sementa, Diana Cash, Karen Higgins, Debbie Spain, Federico Turkheimer, Inge Mick, Sudhakar Selvaraj, David J. Nutt, Anne Lingford-Hughes, Oliver D. Howes, Declan G. Murphy, Jacqueline Borg GABA A receptor availability is not altered in adults with autism spectrum disorder or in mouse models published pages: eaam8434, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aam8434 |
Science Translational Medicine 10/461 | 2020-04-16 |
2019 |
Julian Tillmann, Antonia San José Cáceres, Chris H. Chatham, Daisy Crawley, Rosemary Holt, Bethany Oakley, Tobias Banaschewski, Simon Baronâ€Cohen, Sven Bölte, Jan K. Buitelaar, Sarah Durston, Lindsay Ham, Eva Loth, Emily Simonoff, Will Spooren, Declan G. Murphy, Tony Charman, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Sarah Baumeister, Christian Beckmann, Thomas Bourgeron, Carsten Bours, M Investigating the factors underlying adaptive functioning in autism in the EUâ€AIMS Longitudinal European Autism Project published pages: 645-657, ISSN: 1939-3806, DOI: 10.1002/aur.2081 |
Autism Research 12/4 | 2020-04-16 |
2019 |
Nico Bast, Tobias Banaschewski, Isabel Dziobek, Daniel Brandeis, Luise Poustka, Christine M. Freitag Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder published pages: , ISSN: 1939-3806, DOI: 10.1002/aur.2178 |
Autism Research | 2020-04-16 |
2018 |
David M. Greenberg, Varun Warrier, Carrie Allison, Simon Baron-Cohen Testing the Empathizing–Systemizing theory of sex differences and the Extreme Male Brain theory of autism in half a million people published pages: 12152-12157, ISSN: 0027-8424, DOI: 10.1073/pnas.1811032115 |
Proceedings of the National Academy of Sciences 115/48 | 2020-04-16 |
2019 |
Covadonga M. DÃaz-Caneja, Hugo Schnack, Kenia MartÃnez, Javier Santonja, Yasser Alemán-Gomez, Laura Pina-Camacho, Carmen Moreno, David Fraguas, Celso Arango, Mara Parellada, Joost Janssen Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders published pages: 1643-1653, ISSN: 1065-9471, DOI: 10.1002/hbm.24475 |
Human Brain Mapping 40/5 | 2020-04-16 |
2019 |
Charlotte M Pretzsch, Bogdan Voinescu, Maria A Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Steven Williams, Declan GM Murphy, Eileen Daly, Gráinne M McAlonan The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD) published pages: 1141-1148, ISSN: 0269-8811, DOI: 10.1177/0269881119858306 |
Journal of Psychopharmacology 33/9 | 2020-04-16 |
2019 |
Štefan Holiga, Joerg F. Hipp, Christopher H. Chatham, Pilar Garces, Will Spooren, Xavier Liogier D’Ardhuy, Alessandro Bertolino, Céline Bouquet, Jan K. Buitelaar, Carsten Bours, Annika Rausch, Marianne Oldehinkel, Manuel Bouvard, Anouck Amestoy, Mireille Caralp, Sonia Gueguen, Myriam Ly-Le Moal, Josselin Houenou, Christian F. Beckmann, Eva Loth, Declan Murphy, Tony Charman, Julian Tillmann, Ch Patients with autism spectrum disorders display reproducible functional connectivity alterations published pages: eaat9223, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aat9223 |
Science Translational Medicine 11/481 | 2020-04-16 |
2019 |
Christine Austin, Paul Curtin, Austen Curtin, Chris Gennings, Manish Arora, Kristiina Tammimies, Johan Isaksson, Charlotte Willfors, Sven Bölte Dynamical properties of elemental metabolism distinguish attention deficit hyperactivity disorder from autism spectrum disorder published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-019-0567-6 |
Translational Psychiatry 9/1 | 2020-04-16 |
2019 |
Eva Loth, David W. Evans Converting tests of fundamental social, cognitive, and affective processes into clinically useful bioâ€behavioral markers for neurodevelopmental conditions published pages: e1499, ISSN: 1939-5078, DOI: 10.1002/wcs.1499 |
Wiley Interdisciplinary Reviews: Cognitive Science | 2020-04-16 |
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The information about "AIMS-2-TRIALS" are provided by the European Opendata Portal: CORDIS opendata.
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