Opendata, web and dolomites

F4TGLUT TERMINATED

Food for thought: monitoring the effects of drugs and diet on neuronal glutamate release using nanoelectrodes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 F4TGLUT project word cloud

Explore the words cloud of the F4TGLUT project. It provides you a very rough idea of what is the project "F4TGLUT" about.

monitor    uniquely    release    occurs    sensors    memory    will    drug    selective    transmission    underlies    host    signaling    chemical    precisely    alzheimer    levels    culture    miniaturized    combination    guidance    therapeutic    synaptic    create    primary    placement    influence    microstructures    signal    cultured    nanoelectrodes    additionally    direct    spatiotemporal    underlie    microfluidic    imaging    diet    equipped    unprecedented    ideal    plays    drugs    monitoring    neurotransmission    triggers    adjacent    fluids    expertise    agents    brain    cellular    significantly    platform    compounds    supplemented    pharmacy    device    pathological    dietary    neurotransmitter    precise    sensitive    fabricated    glutamate    extensive    neurons    innervated    plasticity    analytical    disease    fundamental    individual    phenomenon    cells    exposure    microfluidics    urge    cell    experiments    nanoliter    activating    modulates    resolution    vitro    combines    synapse   

Project "F4TGLUT" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 191˙852.00

Map

 Project objective

Glutamate is the primary activating neurotransmitter in the brain. It modulates synaptic plasticity of neurons, which underlies memory formation. However, it also plays a fundamental role in pathological processes, such as those related to Alzheimer’s disease. This essential role and future development of therapeutic agents urge the development of a highly-sensitive analytical method for determining glutamate levels at a cellular level. In this project I will create a miniaturized, in vitro system that will allow this. To develop it, my expertise in microfluidics and pharmacy will be supplemented by the host’s extensive experience with cell analysis and nanoelectrodes.

When glutamate-type neurons in the brain are innervated, glutamate release into the synapse between adjacent neurons occurs. This triggers chemical signal transmission. Nanoelectrodes are uniquely equipped to monitor this neurotransmitter release with unprecedented spatiotemporal resolution. The combination with microfluidics will allow control of fluids and experiments at the nanoliter scale. Furthermore, through precisely fabricated microstructures, guidance of cell growth and precise placement of the nanoelectrodes in the device will be achieved.

Glutamate modulates synaptic plasticity, a phenomenon understood to underlie memory formation. Furthermore, dietary compounds and drugs can influence glutamate neurotransmission. The proposed system enables selective exposure of individual neurons cultured in the microfluidic device to such compounds. Using the integrated nanoelectrodes, direct monitoring of their effects on chemical signaling between cells will be possible. The results will significantly contribute to our understanding of glutamate neurotransmission, and how drugs and diet can influence it. Additionally, the system combines cell culture, selective exposure and analyses at the cellular level using sensors and imaging, making it an ideal platform for future drug development research.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "F4TGLUT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "F4TGLUT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

INTERGLP1 (2020)

Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools

Read More