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INO3D SIGNED

Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Total Cost €

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EC-Contrib. €

0

Partnership

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 INO3D project word cloud

Explore the words cloud of the INO3D project. It provides you a very rough idea of what is the project "INO3D" about.

base    expression    pathological    pairs    cell    complexes    em    nucleosome    generates    differentiation    human    senses    reveal    shaping    dna    promoter    breaks    landscape    models    generating    poorly    subunits    quantitative    complexity    remodelling    di    chemo    consisting    underlying    atp    megadalton    endeavour    maintenance    nucleosomes    transformations    structures    arrays    structural    explore    combination    15    fungal    roles    edit    identity    ino80    assays    regions    species    chromosomal    central    reactions    principles    cryo    collectively    tool    derive    mechanisms    free    functional    nuclear    machines    breaking    fundamental    cells    barrier    protein    editing    protect    wrapped    remodeller    ground    genome    chromatin    gene    octamer    composition    molecular    mechanistic    replication    manner    revealing    shape    histone    147    remodellers    dependent    ends    framework    biological    positioning    repair    move    mechanical    understand    play    position    carry   

Project "INO3D" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙201˙875 €
 EC max contribution 2˙201˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙201˙875.00

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 Project objective

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.

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