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INO3D SIGNED

Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Total Cost €

0

EC-Contrib. €

0

Partnership

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 INO3D project word cloud

Explore the words cloud of the INO3D project. It provides you a very rough idea of what is the project "INO3D" about.

mechanistic    cryo    edit    move    biological    molecular    cell    dependent    play    breaking    quantitative    generating    pathological    repair    reactions    wrapped    principles    genome    differentiation    octamer    explore    complexes    identity    senses    collectively    remodeller    ends    editing    shaping    mechanical    species    pairs    shape    landscape    cells    nucleosomes    endeavour    manner    147    chromosomal    15    machines    promoter    models    positioning    poorly    revealing    position    understand    em    fundamental    mechanisms    megadalton    composition    remodelling    di    roles    derive    subunits    combination    protein    reveal    gene    protect    atp    maintenance    chromatin    structural    barrier    nucleosome    human    assays    chemo    base    replication    breaks    functional    dna    transformations    central    remodellers    histone    carry    structures    underlying    framework    free    nuclear    ground    consisting    generates    ino80    complexity    regions    fungal    expression    arrays    tool   

Project "INO3D" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙201˙875 €
 EC max contribution 2˙201˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙201˙875.00

Map

 Project objective

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.

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