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BreakingBarriers SIGNED

Targeting endothelial barriers to combat disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BreakingBarriers project word cloud

Explore the words cloud of the BreakingBarriers project. It provides you a very rough idea of what is the project "BreakingBarriers" about.

lining    edema    molecular    cell    interfering    disease    blood    obesity    coordinated    barrier    restrict    implications    models    chronic    vivo    homeostasis    inflammation    ultrastructural    contrast    contributes    paracellular    opposing    lipid    cardiovascular    lower    junctions    endothelial    manipulated    drug    underlying    functions    drained    extravasated    adult    validated    accumulation    diametrically    neurodegeneration    mouse    unbalanced    permeability    functional    promise    histological    combination    macromolecules    genetic    altered    mechanisms    opening    ec    gut    leads    function    ecs    tight    cells    pathological    critical    lymphatic    vessels    pioneering    purposes    plasma    bbb    fluid    seek    demand    immune    prevention    vessel    capillary    mechanistic    form    defects    neurovascular    effectors    macromolecule    lack    brain    therapeutic    clearance    gain    treatment    lcb    malfunction    tissue    barriers   

Project "BreakingBarriers" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙499˙969 €
 EC max contribution 2˙499˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙499˙969.00

Map

 Project objective

Tissue homeostasis requires coordinated barrier function in blood and lymphatic vessels. Opening of junctions between endothelial cells (ECs) lining blood vessels leads to tissue fluid accumulation that is drained by lymphatic vessels. A pathological increase in blood vessel permeability or lack or malfunction of lymphatic vessels leads to edema and associated defects in macromolecule and immune cell clearance. Unbalanced barrier function between blood and lymphatic vessels contributes to neurodegeneration, chronic inflammation, and cardiovascular disease. In this proposal, we seek to gain mechanistic understanding into coordination of barrier function between blood and lymphatic vessels, how this process is altered in disease models and how it can be manipulated for therapeutic purposes. We will focus on two critical barriers with diametrically opposing functions, the blood-brain barrier (BBB) and the lymphatic capillary barrier (LCB). ECs of the BBB form very tight junctions that restrict paracellular access to the brain. In contrast, open junctions of the LCB ensure uptake of extravasated fluid, macromolecules and immune cells, as well as lipid in the gut. We have identified novel effectors of BBB and LCB junctions and will determine their role in adult homeostasis and in disease models. Mouse genetic gain and loss of function approaches in combination with histological, ultrastructural, functional and molecular analysis will determine mechanisms underlying formation of tissue specific EC barriers. Deliverables include in vivo validated targets that could be used for i) opening the BBB on demand for drug delivery into the brain, and ii) to lower plasma lipid uptake via interfering with the LCB, with implications for prevention of obesity, cardiovascular disease and inflammation. These pioneering studies promise to open up new opportunities for research and treatment of neurovascular and cardiovascular disease.

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The information about "BREAKINGBARRIERS" are provided by the European Opendata Portal: CORDIS opendata.

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