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BreakingBarriers SIGNED

Targeting endothelial barriers to combat disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BreakingBarriers project word cloud

Explore the words cloud of the BreakingBarriers project. It provides you a very rough idea of what is the project "BreakingBarriers" about.

treatment    paracellular    cardiovascular    opening    altered    function    extravasated    permeability    vivo    lymphatic    opposing    restrict    gut    lipid    inflammation    barrier    cell    unbalanced    form    adult    plasma    vessel    molecular    edema    barriers    ec    lining    gain    endothelial    immune    malfunction    tissue    bbb    ecs    vessels    lack    neurovascular    pioneering    purposes    junctions    histological    brain    validated    coordinated    homeostasis    critical    disease    functional    contributes    lower    prevention    promise    macromolecule    lcb    ultrastructural    implications    leads    mechanisms    blood    mouse    tight    contrast    diametrically    functions    macromolecules    effectors    genetic    capillary    obesity    combination    seek    neurodegeneration    demand    therapeutic    manipulated    underlying    drug    defects    clearance    interfering    models    accumulation    chronic    mechanistic    cells    pathological    fluid    drained   

Project "BreakingBarriers" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙499˙969 €
 EC max contribution 2˙499˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙499˙969.00

Map

 Project objective

Tissue homeostasis requires coordinated barrier function in blood and lymphatic vessels. Opening of junctions between endothelial cells (ECs) lining blood vessels leads to tissue fluid accumulation that is drained by lymphatic vessels. A pathological increase in blood vessel permeability or lack or malfunction of lymphatic vessels leads to edema and associated defects in macromolecule and immune cell clearance. Unbalanced barrier function between blood and lymphatic vessels contributes to neurodegeneration, chronic inflammation, and cardiovascular disease. In this proposal, we seek to gain mechanistic understanding into coordination of barrier function between blood and lymphatic vessels, how this process is altered in disease models and how it can be manipulated for therapeutic purposes. We will focus on two critical barriers with diametrically opposing functions, the blood-brain barrier (BBB) and the lymphatic capillary barrier (LCB). ECs of the BBB form very tight junctions that restrict paracellular access to the brain. In contrast, open junctions of the LCB ensure uptake of extravasated fluid, macromolecules and immune cells, as well as lipid in the gut. We have identified novel effectors of BBB and LCB junctions and will determine their role in adult homeostasis and in disease models. Mouse genetic gain and loss of function approaches in combination with histological, ultrastructural, functional and molecular analysis will determine mechanisms underlying formation of tissue specific EC barriers. Deliverables include in vivo validated targets that could be used for i) opening the BBB on demand for drug delivery into the brain, and ii) to lower plasma lipid uptake via interfering with the LCB, with implications for prevention of obesity, cardiovascular disease and inflammation. These pioneering studies promise to open up new opportunities for research and treatment of neurovascular and cardiovascular disease.

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The information about "BREAKINGBARRIERS" are provided by the European Opendata Portal: CORDIS opendata.

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