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FRAME SIGNED

FRAME - tumor genome-based personalized anti-cancer vaccines off-the-shelf

Total Cost €

EC-Contrib. €

Partnership

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FRAME project word cloud

Explore the words cloud of the FRAME project. It provides you a very rough idea of what is the project "FRAME" about.

crucell frames sequences develops entirely health therapeutic routinely time manufacturing successful patients off days neoantigens months personalized point effect foreign melanoma shift therapeutics benefit clinical vaccines treatment entrepreneurs types team founder shelf discovered colon dutch consists proqr patient licensed expressed frameshift group quo kidney healthy immune start costly activation critical alone checkpoint source requiring strategies combine shown inhibitors activate ceo record dna solution frame individualized read care alter mutations ambition shared cancers reducing vaccination cancer lung tumor usually 50 weeks balanced economics strategy ratio uterine company body vaccine entire first status breaking track anti ground breast imprcost biotech

Project "FRAME" data sheet

The following table provides information about the project.

Coordinator	FRAME PHARMACEUTICALS BV Organization address address: Science Park 106 city: AMSTERDAM postcode: 1098 XG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2019
Duration (year-month-day)	from 2019-08-01 to 2020-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FRAME PHARMACEUTICALS BV FRAME PHARMACEUTICALS BV Organization address address: Science Park 106 city: AMSTERDAM postcode: 1098 XG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	50˙000.00

Map

Project objective

Frame Cancer Therapeutics is a Dutch start-up that develops effective vaccines against cancer, based on frameshift mutations. Driven by the ambition to provide a therapeutic effect for up to 50% of all cancers, Frame aims to alter the status quo of cancer treatment. Our balanced team consists of top researchers and successful biotech entrepreneurs with a track record including the CEO of Crucell , and founder of ProQR.

The clinical use of so-called checkpoint inhibitors, which activate the immune system, has shown great effects, particularly for treatment of advanced melanoma. Yet, a large group of cancer patients does not benefit from this treatment alone, and the next step is to combine this general activation of the immune system with tumor-specific vaccination. This has just become possible now that entire tumor DNA sequences get to be routinely read within two weeks, as part of clinical care.

The solution that Frame Cancer Therapeutics has developed is a ground-breaking strategy for anti-cancer vaccination using off-the-shelf yet personalized cancer vaccines derived from frameshift mutations. Frame Therapeutics has discovered FRAMES, a source of shared neoantigens induced by frame-shift mutations with unique therapeutic potential. These sequences are usually not expressed in the healthy body, and thus seen as foreign by the immune system. A licensed sets of FRAMES are each specific vaccines for different tumor types (such as breast, lung, kidney, colon, uterine cancer).

Most cancer vaccination strategies are based on point mutations unique for each tumor, requiring costly individualized vaccine manufacturing. Frame Therapeutics is the first company entirely focusing on the development of cancer vaccines based on FRAMES, offering off-the-shelf personalized cancer vaccines. This approach allows for economics of scale, reducing time to treatment from months to days, which is critical to patient health, and which will imprcost/benefit ratio’s.

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The information about "FRAME" are provided by the European Opendata Portal: CORDIS opendata.

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