Opendata, web and dolomites
CHANCE SIGNED
Structure guided inhibition of IDOL to treat atherosclerosis and the metabolic syndrome
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0CHANCE project word cloud
Explore the words cloud of the CHANCE project. It provides you a very rough idea of what is the project "CHANCE" about.
diabetes
expenditure
dyslipidemia
validation
prevalence
ubiquitin
virtual
unicom
fatty
detrimental
mice
resolution
disorders
mets
30
reached
erc
epidemic
morbidities
epidemiologic
concomitantly
optimal
cardiovascular
3d
inhibition
ligase
liver
ligand
combines
mainstay
comorbidities
pipeline
small
proportions
suggests
protocol
obesity
pcsk9
inhibitors
treatment
strategy
therapeutic
treatments
absence
guided
hampered
statins
ip
e3
protects
validate
prohibitively
lacking
sustainable
cog
expensive
docking
disease
genetic
risk
capitalize
world
treating
molecule
healthcare
co
idol
modalities
substantial
chance
vitro
hits
metabolic
lowering
multiple
reduce
business
structure
discovered
vivo
lipid
despite
Project "CHANCE" data sheet
The following table provides information about the project.
| Coordinator |
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-10-01 to 2021-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM | NL (AMSTERDAM) | coordinator | 150˙000.00 |
Map
Project objective
The prevalence of the MetS and associated co-morbidities including cardiovascular disease has reached epidemic proportions in the developed and developing world. The cost of treating these conditions represents a substantial part of current European healthcare expenditure, and despite recent advances, treatments for MetS-associated lipid disorders are far from optimal; mainstay lipid-lowering treatments (e.g. statins) reduce cardiovascular risk by only ~30%, and recently-introduced PCSK9 inhibitors are promising, but prohibitively expensive. Moreover, epidemiologic and genetic evidence suggests that these treatment modalities are associated with a significant increase in the risk for development of diabetes. Treatments for other MetS-associated comorbidities, including dyslipidemia, diabetes, obesity, and fatty-liver disease are far from optimal or lacking. In ERC-CoG UNICOM we discovered that genetic inhibition of the E3-ubiquitin ligase IDOL protects mice from the detrimental development of multiple MetS-associated comorbidities. We therefore propose IDOL inhibition as a novel therapeutic strategy to concomitantly target multiple metabolic co-morbidities. However, absence of a high resolution IDOL structure has hampered structure-guided development of inhibitors. In CHANCE, we will capitalize on the high resolution 3D structure of IDOL that we recently obtained. Using this unique structure we aim to identify and validate small-molecule IDOL inhibitors by using a structure-guided development pipeline that combines an established virtual ligand docking protocol, and in vitro and in vivo validation. Lead hits will be used for development of a business and IP strategy to ensure the sustainable development of IDOL inhibitors for treating the MetS.
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The information about "CHANCE" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-16 10:34:32) correctly updated