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TOX-ANT SIGNED

Toxin-antidote selfish elements in animals: from gene drive to speciation

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TOX-ANT project word cloud

Explore the words cloud of the TOX-ANT project. It provides you a very rough idea of what is the project "TOX-ANT" about.

evo    effect    genetics    surprisingly    mosquito    biochemistry    animals    devo    balancing    adults    contribution    decade    zika    action    genomics    mimicking    questions    selfish    multidisciplinary    tropicalis    qtl    prevalence    synthetic    global    molecular    examples    efficient    spreading    medicine    suggests    animal    close    dissected    bulk    spread    critical    team    mechanism    pha    extremely    genetically    laws    diverse    vectors    unknown    fitness    species    natural    screen    first    health    biology    mendelian    challenged    dissecting    vertebrates    dissect    relative    idea    subverting    class    diseases    elegans    discover    anticipated    lack    populations    gene    view    perpetuated    medaka    time    largely    rare    ta    underlying    antidote    speciation    discovered    expertise    stimulate    leveraging    malaria    previously    nematodes    raises    acting    origin    antagonize    nematode    mapping    paternal    drive    mechanisms    evolutionary    sup    virus    segregation    35    predict    toxin    burdens    fish   

Project "TOX-ANT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH 

Organization address
address: DR BOHRGASSE 3
city: WIEN
postcode: 1030
website: www.imba.oeaw.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙498˙428 €
 EC max contribution 1˙498˙428 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) coordinator 1˙498˙428.00

Map

 Project objective

Toxin-antidote (TA) elements are a class of selfish elements that spread in natural populations by subverting the laws of Mendelian segregation (gene drive activity). For a decade, the only known TA element in animals was a paternal-acting element discovered in the nematode C. elegans. The lack of other examples perpetuated the idea that TA elements were extremely rare in animals. However, I recently challenged this view with two key findings 1) I genetically dissected a second TA element in C. elegans, the element sup-35/pha-1, and 2) I identified five novel TA elements in C. tropicalis, a close relative of C. elegans. Surprisingly, some of these novel TA elements can affect the fitness of adults and can antagonize each other mimicking the effect of balancing selection. Overall, my research strongly suggests that TA elements are much more common in animals than previously anticipated and raises critical questions about their origin, prevalence, mechanism of action, and contribution to speciation, all of which are largely unknown. This proposal has three main objectives: 1. To dissect the molecular mechanisms underlying an animal TA element for the first time. 2. To identify and characterize novel TA elements in diverse nematode species. 3. To screen for TA elements in medaka fish. My team and I will achieve these objectives by leveraging my multidisciplinary expertise in genomics, evo-devo, and biochemistry, as well as a state-of-the-art bulk QTL mapping method that I recently developed. Dissecting the molecular mechanisms used by natural selfish elements will help us design more efficient and specific synthetic drive elements that could target mosquito vectors spreading diseases such as malaria and Zika virus - global health burdens. I predict that we will discover and characterize many novel TA selfish elements in diverse species from nematodes to vertebrates. Our findings will stimulate new research areas in genetics, evolutionary biology, and medicine.

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