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CLAUSTROFUNCT SIGNED

Claustrum function in cortical processing and putative claustral dysfunction in schizophrenia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CLAUSTROFUNCT project word cloud

Explore the words cloud of the CLAUSTROFUNCT project. It provides you a very rough idea of what is the project "CLAUSTROFUNCT" about.

unknown    expression    cortices    exact    deficits    communication    brain    causal    search    normal       incidence    causes    evidences    levels    functions    lesions    impaired    hallucinations    summary    centers    suggest    hypothesize    potentially    transient    shed    associative    prefrontal    chronic    cognitive    reports    enigmatic    cla    receptor    uniquely    link    dysfunction    cortical    patients    network    genes    delusions    risk    underlying    executive    kappa    mechanisms    function    worldwide    nature    opioid    suggesting    altered    combination    disease    selectively    medical    hallucinogenic    positioned    mouse    cortex    establishing    mental    influence    symptoms    peculiar    structure    subcortical    schizophrenia    found    drug    interconnected    regulating    potent    pfc    reciprocally    works    circuit    played    neocortex    claustrum    pathology    expressing    salvinorin    led    light    permanent    concomitantly    malfunction    highest    traits    behavioral    expressed    circuits   

Project "CLAUSTROFUNCT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE GENEVE 

Organization address
address: RUE DU GENERAL DUFOUR 24
city: GENEVE
postcode: 1211
website: www.unige.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 5˙000˙000 €
 EC max contribution 5˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2026-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 5˙000˙000.00

Map

 Project objective

Schizophrenia is a chronic mental disease having an incidence of 1% worldwide. Its symptoms are numerous and range from hallucinations to altered executive functions. Although the exact causes of schizophrenia are unknown, several works suggest that impaired communication between higher cortical centers may be important for the expression of the disease. Establishing a causal link between circuit function (and/or dysfunction) and particular behavioral traits relevant to schizophrenia may shed new light on the mechanisms underlying the pathology. Dysfunction of the prefrontal cortex (PFC) may contribute to cognitive deficits relevant to schizophrenia. In a search for circuits potentially regulating the PFC, we identified an enigmatic and not well-studied network, the claustrum (CLA). This subcortical structure of unknown function is supposed to be highly reciprocally interconnected with the neocortex, especially associative cortices involved in behavioral traits relevant to schizophrenia. It is thus uniquely positioned to influence cortical communication. The CLA is also peculiar because it represents the brain structure expressing the highest levels of kappa opioid receptor, the receptor of the most potent hallucinogenic drug found in nature, salvinorin A, suggesting a potential role played by the CLA in hallucinations. This link is further supported by medical reports in which patients having transient or permanent lesions in the claustrum develop hallucinations and delusions concomitantly. Finally, many risk factors genes associated to schizophrenia are strongly and often selectively expressed in the mouse claustrum. In summary, this combination of evidences led us to hypothesize that the claustrum may represent a circuit whose malfunction is relevant to the expression of schizophrenia. Our proposal will test the role of the claustrum in the normal brain and test whether its dysfunction may contribute to schizophrenia symptoms.

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The information about "CLAUSTROFUNCT" are provided by the European Opendata Portal: CORDIS opendata.

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