TIMER

TargetIng novel MEchanisms of Resolution in inflammation

Coordinatore	FONDAZIONE HUMANITAS PER LA RICERCA    more  Organization address address: Via Manzoni 56 city: ROZZANO postcode: 20089 contact info Titolo: Dr. Nome: Danilo Cognome: Petroni Email: send email Telefono: +39 02 82242435 Fax: +39 02 82245191
Nazionalità Coordinatore	Italy [IT]
Totale costo	3˙989˙175 €
EC contributo	2˙999˙300 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-single-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE HUMANITAS PER LA RICERCA  Organization address address: Via Manzoni 56 city: ROZZANO postcode: 20089 contact info Titolo: Dr. Nome: Danilo Cognome: Petroni Email: send email Telefono: +39 02 82242435 Fax: +39 02 82245191	IT (ROZZANO)	coordinator	597˙503.54
2	FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA  Organization address address: Via Vincenzo Vela 6 city: BELLINZONA postcode: 6500 contact info Titolo: Prof. Nome: Giorgio Cognome: Noseda Email: send email Telefono: +41 91 820 0309 Fax: +41 91 820 0305	CH (BELLINZONA)	participant	363˙600.00
3	UNIVERSITY OF GLASGOW  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Ms. Nome: Adriana Cognome: Scicluna Email: send email Telefono: +44 141 330 4646 Fax: +44 141 330 5856	UK (GLASGOW)	participant	357˙600.00
4	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: 35318961942 Fax: 35317071633	IE (DUBLIN)	participant	297˙600.00
5	TELORMEDIX SA  Organization address address: Via della Posta 10 city: Bioggio postcode: 6934 contact info Titolo: Dr. Nome: Johanna Cognome: Holldack Email: send email Telefono: 41916107038 Fax: 41912606836	CH (Bioggio)	participant	289˙696.46
6	UNIVERSIDADE FEDERAL DE MINAS GERAIS  Organization address address: AV. ANTONIO CARLOS - PAMPULHA 6627 city: BELO HORIZONTE MINAS GERAIS postcode: 31270901 contact info Titolo: Dr. Nome: Marco Aurelio Cognome: Crocco Afonso Email: send email Telefono: +55 31 3409 4200 Fax: +55 31 3409 4252	BR (BELO HORIZONTE MINAS GERAIS)	participant	250˙500.00
7	FUNDACAO OSWALDO CRUZ  Organization address address: AVENIDA BRASIL 4365 city: RIO DE JANEIRO postcode: 21040 900 contact info Titolo: Prof. Nome: Adolfo Horácio Cognome: Chorny Email: send email Telefono: +55 21 2209 2600 Fax: +55 21 22092295	BR (RIO DE JANEIRO)	participant	222˙000.00
8	UNIVERSIDADE DE SAO PAULO  Organization address address: RUA DA REITORIA 109 BUTANTA city: SAO PAULO SP postcode: 05508 900 contact info Titolo: Prof. Nome: Antonio Marcos De Aguirra Cognome: Massola Email: send email Telefono: +55 11 3035 0550 Fax: +55 11 3035 0580	BR (SAO PAULO SP)	participant	220˙800.00
9	NOVIMMUNE SA  Organization address address: CHEMIN DES AULX 14 city: PLAN LES OUATES GENEVE postcode: 1228 contact info Titolo: Mrs. Nome: Nathalie Cognome: Muller Email: send email Telefono: +41 22 593 5104 Fax: +41 22 839 7143	CH (PLAN LES OUATES GENEVE)	participant	163˙037.00
10	ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU  Organization address address: VIA FIORENTINA 151 city: SIENA postcode: 53100 contact info Titolo: Dr. Nome: Cristiana Cognome: Tozzi Email: send email Telefono: +39 0577 587906 Fax: +39 0577 593815	IT (SIENA)	participant	100˙000.00
11	DOMPE FARMACEUTICI SPA  Organization address address: VIA S MARTINO DELLA BATTAGLIA 12 city: MILANO postcode: 20122 contact info Titolo: Dr. Nome: Cinzia Cognome: D'ettorre Email: send email Telefono: +39 0862 338324 Fax: +39 0862 338219	IT (MILANO)	participant	100˙000.00
12	MERCK SERONO SA  Organization address address: Chemin des Mines 9 city: GENEVE postcode: 1202 contact info Titolo: Mr. Nome: Albert Cognome: Pitteloud Email: send email Telefono: +41 22 739 3865 Fax: +41 22 739 3063	CH (GENEVE)	participant	36˙963.00
13	DOMPE SPA  Organization address address: Via Campo di Pile city: L'Aquila postcode: 67100 contact info Titolo: Dr. Nome: Cinzia Cognome: D'ettorre Email: send email Telefono: +39 0862 338324 Fax: +39 0862 338219	IT (L'Aquila)	participant	0.00

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 Obiettivo del progetto (Objective)

'Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will involve discovery of new natural or synthetic “pro-resolving” molecules for plant and animals and investigation on endogenous inflammation “pro-resolving” mechanisms identified by various partners of the Consortium, including atypical chemokine receptors, decoy receptors, and microRNA. Tapping resources of natural compounds will be a major thrust. Efforts will be mainly focused on the regulation by “pro-resolving” agents on two molecular systems of key relevance in inflammation: the chemokine system, which regulates recruitment, permanence and egress of leukocyte in tissues; and the TLR/IL-1R system, which is central for the activation of infiltrating leukocytes. To this purpose, the project will capitalize on, and bring added value to a strong tradition of the Consortium in the fields of: leukocyte recruitment and activation; negative regulators of inflammation; industrial-academic collaboration; identification and characterization of innovative inhibitors of natural origin; European-Brazilian collaboration.'

Introduzione (Teaser)

Although inflammation is desirable to maintain health, the inability to resolve inflammatory responses can alter tissue homeostasis and cause disease. A group of European researchers is taking advantage of the physiological mechanisms that resolve inflammation to design drugs for treating chronic conditions.

Descrizione progetto (Article)

Inflammation is the complex response of our immune system to get rid of harmful stimuli, including pathogens.

Pathological chronic inflammation is known to be associated with many conditions including cancer, neurodegeneration and many autoimmune diseases.

The aim of the EU-funded 'Targeting novel mechanisms of resolution in inflammation' (http://www.eumbrella.org/timer.html (TIMER)) project is to identify and validate new molecules involved in the resolution of inflammation.

By focusing on the cells that sustain inflammation, the consortium hopes to provide the basis for the development of innovative therapeutic strategies.

The concept behind the TIMER study lies on the resolution of inflammation rather than on the passive blockade of pro-inflammatory mediators.

Through natural or synthetic 'pro-resolving' molecules, partners will target two key pathways of inflammation, namely the chemokine and the toll-like receptor (TLR) systems.

Chemokines work to attract leukocytes to sites of inflammation where they become activated by macrophages or dendritic cells through TLRs.

So far, researchers have unveiled three different mechanisms controlling inflammation.

The molecule TIR8 has been shown to promote the resolution of inflammation by blocking both chemokine and TLR pathways.

Resolution of inflammation has also been found to depend on microRNA molecules as well as on metabolic molecules.

Partners have worked on providing solutions to resolve inflammation in the form of synthetic or natural peptides and TLR-binding agonists.

Some of these have shown promising results in pre-clinical models and their efficacy is being further evaluated in a human clinical study.

By shedding light onto the mechanisms that resolve inflammation, the TIMER study proposes to use both endogenous and exogenous molecules that can regulate the inflammatory process.

The generated information could be exploited for the design of novel therapies and pro-resolving drugs that can alleviate the detrimental impact of chronic inflammation.