NANOSYM

Symbiotic bacteria as a delivery system for Nanobodies that target the insect-parasite interplay

Coordinatore	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Belgium [BE]
Totale costo	1˙444˙370 €
EC contributo	1˙444˙370 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2016-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE  Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 contact info Titolo: Dr. Nome: Jan Cognome: Van Den Abbeele Email: send email Telefono: +32 3 2476262 Fax: +32 3 2476268	BE (ANTWERPEN)	hostInstitution	1˙444˙370.40
2	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE  Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 contact info Titolo: Ms. Nome: Nadine Cognome: Van Peer Email: send email Telefono: +32 3 247 62 02 Fax: +32 3 247 62 33	BE (ANTWERPEN)	hostInstitution	1˙444˙370.40

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 Obiettivo del progetto (Objective)

'The tsetse fly (Glossina spp.) salivary gland is the final micro-environment where the Trypanosoma brucei parasites adhere and undergo a complex re-programming cycle resulting in an end stage that is re-programmed to continue its life cycle in a new mammalian host. The molecular parasite-vector communications that orchestrate this trypanosome development in tsetse fly salivary glands remain unknown mainly due to the limited availability of experimental tools for functional research. We hypothesize that an innovative paratransgenic approach using the Sodalis glossinidius endosymbiont to deliver Nanobodies that target the trypanosome-tsetse fly crosstalk will open a new avenue to unravel the molecular determinants of this specific parasite-vector association. In this project I will develop an innovative Sodalis-based internal delivery system for Nanobodies to target the tsetse fly – trypanosome interplay and, as final outcome, will generate a trypanosome-resistant tsetse fly. In addition, I will explore the completely ‘unknown’ of the molecular nature of trypanosome adherence to the salivary gland epithelium. This will be addressed by a challenging proteomic-based approach on the tsetse salivary gland - trypanosome membrane complex and by the newly developed paratransgenic approach using the S. glossinidius endosymbiont as an internal delivery system for salivary gland epithelium-targeting Nanobodies. The application of this innovative concept of using pathogen-targeting Nanobodies delivered by insect symbiotic bacteria could be extended to other vector-pathogen systems such as Anopheles gambiae – Plasmodium falciparum and Aedes aegypti – dengue virus.'