HYDRAGLUE

Hydra Glue: Bioadhesion of a freshwater polyp

 Coordinatore  

 Organization address address: INNRAIN 52
city: INNSBRUCK
postcode: 6020

contact info
Titolo: Dr.
Nome: Peter
Cognome: Ladurner
Email: send email
Telefono: +43 51250751841
Fax: +43 51250751899

 Nazionalità Coordinatore Non specificata
 Totale costo 179˙137 €
 EC contributo 0 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-01   -   2016-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET INNSBRUCK

 Organization address address: INNRAIN 52
city: INNSBRUCK
postcode: 6020

contact info
Titolo: Dr.
Nome: Peter
Cognome: Ladurner
Email: send email
Telefono: +43 51250751841
Fax: +43 51250751899

AT (INNSBRUCK) coordinator 179˙137.20

Mappa


 Word cloud

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biological    disc    hydra    engineering    genes    analysed    basal    adhesive    adhesives    organism    selected    wet    adhesion   

 Obiettivo del progetto (Objective)

'A fundamental challenge in materials science is engineering durable adhesive bonds in a wet environment. Biological adhesives offer remarkable performances in their natural context and have the potential to inspire novel adhesives for an increasing variety of biotechnologies applications, providing more elegant solutions to modern engineering and biomedical adhesive requirements. The main goal of my project is identifying novel molecules that are involved in biological adhesion using as model organism the cnidarian Hydra magnipapillata. This species harbours several features that render it as suited to study biological adhesion including the strong adhesion in wet surfaces through basal disc-secreting-mucous cells, the state-of-the-art methodological toolbox and, the excellent knowledge of the biological features of this organism. I will gradually narrow down the number of candidate genes that are involved in adhesion, by: first, generating a highly basal disc specific transcriptome database followed by in-situ hybridization screen of basal disc specific genes. Next, knockdown of selected genes will be performed using RNA interference which will result in a non-adhesive phenotype. As of phenotypic validation by electron microscopy, genes will be selected to generate polyclonal antibodies, to further pull-down the adhesive proteins which will then be analysed by Mass Spectometry. The carbohydrate components involved in adhesion will additionally be investigated using lectin staining. Using this iterative multidisciplinary approach, the adhesion´s mechanism can be experimentally studied, and theoretically analysed in order to bring innovative bio-inspired adhesives to the market. Expected outcomes will ultimately to process the appropriate protein/s into useful application that mimics their adapted functions in the Hydra.'

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