INGENIUM

Studying Physiology and Pathology of Imprinted Genes to understand the role of Epigenetic Mutations in Human Disease

Coordinatore	CONSIGLIO NAZIONALE DELLE RICERCHE    more  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Mr. Nome: Alfredo Cognome: Di Giacomo Email: send email Telefono: +39081 6132419 Fax: +39 081 6132709
Nazionalità Coordinatore	Italy [IT]
Totale costo	3˙662˙880 €
EC contributo	3˙662˙880 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-ITN
Funding Scheme	MC-ITN
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-04-01   -   2016-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Mr. Nome: Alfredo Cognome: Di Giacomo Email: send email Telefono: +39081 6132419 Fax: +39 081 6132709	IT (ROMA)	coordinator	696˙689.98
2	THE BABRAHAM INSTITUTE  Organization address address: Babraham Hall city: CAMBRIDGE postcode: CB22 3AT contact info Titolo: Dr. Nome: Caroline Cognome: Edmonds Email: send email Telefono: 441223000000 Fax: 441223000000	UK (CAMBRIDGE)	participant	553˙201.99
3	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Isabelle Cognome: Verdier Email: send email Telefono: 33148073433	FR (PARIS)	participant	538˙992.00
4	KOBENHAVNS UNIVERSITET	DK	participant	306˙748.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Jocelyn Cognome: Mere Email: send email Telefono: 33467613535 Fax: 33467043236	FR (PARIS)	participant	277˙195.01
6	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: 441223000000 Fax: 441223000000	UK (CAMBRIDGE)	participant	271˙100.01
7	THE UNIVERSITY OF BIRMINGHAM  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Ms. Nome: May Cognome: Chung Email: send email Telefono: 441214000000 Fax: 441214000000	UK (BIRMINGHAM)	participant	271˙100.01
8	DIAGENODE  Organization address address: RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE city: SERAING postcode: 4102 contact info Titolo: Mr. Nome: Leon Cognome: Etienne Email: send email Telefono: 32043642062 Fax: 32043642051	BE (SERAING)	participant	255˙068.00
9	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Didier Cognome: Trono Email: send email Telefono: 41216931751 Fax: 41216939538	CH (LAUSANNE)	participant	254˙681.00
10	FUNDACIO CENTRE DE REGULACIO GENOMICA  Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 contact info Titolo: Ms. Nome: Mariana Cognome: Morlans Email: send email Telefono: +34 93 3160108 Fax: 34933969983	ES (BARCELONA)	participant	238˙104.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulation and Imprinting Disorders (IDs). This ITN brings together different expertise from both public and private sectors with the aim of investigating the physiology and pathology of Genomic Imprinting. We propose to define mechanisms, molecular factors and pathways regulating DNA-methylation and chromatin dynamics involved in gene expression control in human health and disease. This concerted approach has the potential to identify new and more effective diagnostic, preventive and therapeutic strategies for IDs, and more generally to elucidate roles and origin of epigenetic mutations in human pathologies, including common diseases. Early stage (ESRs) and experienced researchers (ERs) will have access to a range of cutting-edge methodologies to enable the application of integrated multidisciplinary strategies to analyse epigenetic phenomena. The excellent scientific and educational environment and the intense public-private sector collaboration will promote high-level training of the young researchers. The ESRs and ERs will acquire experience and expertise in a variety of disciplines, including molecular, cellular and developmental biology, genomics, bioinformatics, chromatin dynamics and epigenetics and phenotypic analysis, and state-of-the-art methodologies such as gene targeting, stem cell culture, epigenetic and chromatin technologies, and massively parallel sequencing. Hence, this ITN will generate a new cohort of scientists trained in contemporary post-genomic biology and able to apply advanced technological tools to investigate human disease in both academia and industry.'

Introduzione (Teaser)

European researchers are studying epigenetic mutations to understand how gene expression is regulated in health and disease. Epigenetics influences which genes will be expressed by factors other than an individual's DNA sequence.