SOUND PHARMA
Image Guided Local Drug Delivery from Nanocarriers using Focused Ultrasound
| Coordinatore | UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 2˙500˙000 € |
| EC contributo | 2˙500˙000 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2010-AdG_20100317 |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-12-01 - 2016-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address
address: HEIDELBERGLAAN 100 contact info |
NL (UTRECHT) | hostInstitution | 2˙500˙000.00 |
| 2 |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address
address: HEIDELBERGLAAN 100 contact info |
NL (UTRECHT) | hostInstitution | 2˙500˙000.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'The principal objective of the Sound Pharma project is to increase the therapeutic index of potent, often toxic treatments through personalized image-guided treatment, which ultimately decreases adverse effects of drugs by better controlling the pharmacokinetics (PK) and pharmacodynamics (PD) of therapy. For local disease, exogenous energy will be used to to release drugs entrapped within nanoparticles circulating through the tumor. This will be achieved via a combination of Focused Ultrasound, and drug nanocarriers that are sensitive to bio-effects of ultrasound. The drug ¿magic bullet¿ is at the heart of Pharma¿s business model. However, targeted drug delivery is increasingly being recognized as a key limiting factor of drug efficacy. Nanotechnologies are providing new formulations as well as novel methods for targeting. The combination of nanotechnologies and external triggering will provide novel technologies to achieve spatio-temporal control of drug delivery. The effect of ultrasound in tissue allows the local deposition of drugs from nanocarriers circulating in the blood, and/or their local activation. This is the case when using nanocarriers sensitive to mechanical forces and/or to small temperature elevations. Extravasation and membrane permeability are also enhanced by ultrasound. This new field of Image Guided Drug Delivery opens up opportunities for Pharma to expand applications for their existing small drugs (e.g. doxorubicin, cisplatin, irinitecan) in cancer by altered pharmacokinetics. This project intends to develop new focused ultrasound methods for drug delivery, based on local control of temperature and pressure, and by monitoring and validating intracellular uptake in real time using optical and MRI methods. The developed FUS methods will be applied to treatment of liver cancer using nanocarriers containing well known chemotherapeutica, via animal models, as well as in the clinic.'