HND

Mechanisms of Human Neuronal Development and Functional Integration in Neural Network

Coordinatore	UNIVERSITE D'AIX MARSEILLE    more  Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 contact info Titolo: Ms. Nome: Céline Cognome: Damon Email: send email Telefono: +33 6 98 97 72 76
Nazionalità Coordinatore	France [FR]
Totale costo	232˙676 €
EC contributo	232˙676 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IOF
Funding Scheme	MC-IOF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-01   -   2015-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE D'AIX MARSEILLE  Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 contact info Titolo: Ms. Nome: Céline Cognome: Damon Email: send email Telefono: +33 6 98 97 72 76	FR (Marseille)	coordinator	232˙676.80

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 Obiettivo del progetto (Objective)

Despite the exponentially growing burden that neurodevelopment or neurodegenerative diseases represent in public health, the therapies are mostly inexistent or very limited. Intensive fundamental research on the biological mechanisms of neurological disorders is strongly needed to discover and validate pharmacological treatments. At the same time, there is a pressing need for treatment that would compensate the loss of neurons occurring in a multitude of neurological disorders. Rare clinical trials have promoted the feasibility of stem cell-based therapy in the human brain. However, when significant, the benefits of the treatment were transient, and did not completely stop the progression of the disease. Unfortunately, the physiological causes of success or failure of the grafts remain unclear. It seems thus crucial to develop new human experimental models to resolve those issues. In this context, the HND proposal is guided by the objective to study the key mechanisms of human neuronal development and more precisely to clarify how human neural progenitors may functionally integrate neural networks. To reach this aim, I will have to achieve the following specific objectives: 1) Developing human experimental neuron-based models, and 2) Developing new strategies to insure the appropriate maturation, integration, function and fate of neural progenitors. The HND project will be performed on neural cell culture obtained from human tissue, by using state-of-the-art genetic reprogramming techniques. The originality of the proposal is to combine several cutting-edge genetic and physiological technologies to approach the topic at cellular and neural network levels in living tissue. The outcomes of the project will be particularly important to research aiming to identify the biological mechanisms underlying neurological pathologies and validate pharmacological treatments, as well as to restorative cell therapies.