LISGENOMICS
Study of the Listeria monocytogenes gene expression profile in ready-to-eat foods of animal origin by the application of the omics and the bioinformatics/biostatistics disciplines
| Coordinatore | UNIVERSITA DEGLI STUDI DI TORINO
Organization address
address: Via Giuseppe Verdi 8 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 50˙000 € |
| EC contributo | 50˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2011-CIG |
| Funding Scheme | MC-CIG |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-12-01 - 2014-05-01 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI TORINO
Organization address
address: Via Giuseppe Verdi 8 contact info |
IT (TORINO) | coordinator | 50˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'Although the rate of food contamination with Listeria monocytogenes is low, the mortality rate that is caused by this microorganism is high, and for this reason, it is placed on the top of the list of pathogens of concern for the public health and consequently for the food industry. L. monocytogenes has emerged as a food-borne pathogen the last decades, due to changes in food processing, consumer habits and the demand for minimally processed foods. The molecular mechanism of virulence has gained a lot of attention and many steps of this complex process have been elucidated to various levels. All L. monocytogenes strains found in foods should be considered to be pathogenic. However, the relative virulence of individual L. monocytogenes isolates can vary substantially. The genetic basis underlying these virulence differences is not yet understood. Differences in gene content exist between strains of different serovars and origins. Differences among strains could also be due to different gene expression/regulation of the core genes of the microorganism. The ability to rapidly determine the pathogenic potential of L. monocytogenes strains is integral to the control and prevention campaign against listeriosis. Throughout the years, different approaches have been employed to assess virulence: in vivo bioassays, in vitro cell assays and targeting virulence-associated proteins and genes. However, these methods have disadvantages such as the need for laboratory animals (bioassays) and the time constraints. Furthermore, targeting virulence genes gives only an indication of the virulence potential of strains. Nowadays, powerful alternatives such as microarrays and reverse transcriptional quantitative polymerase chain reaction (RT-qPCR) are available that can assist in the definition of the virulence potential of L. monocyotogenes strains by the means of modelling.'