LISGENOMICS

Study of the Listeria monocytogenes gene expression profile in ready-to-eat foods of animal origin by the application of the omics and the bioinformatics/biostatistics disciplines

Coordinatore	UNIVERSITA DEGLI STUDI DI TORINO    more  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Dr. Nome: Luca Cognome: Cocolin Email: send email Telefono: +39 011 6708553 Fax: +39 011 6708549
Nazionalità Coordinatore	Italy [IT]
Totale costo	50˙000 €
EC contributo	50˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-12-01   -   2014-05-01

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI TORINO  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Dr. Nome: Luca Cognome: Cocolin Email: send email Telefono: +39 011 6708553 Fax: +39 011 6708549	IT (TORINO)	coordinator	50˙000.00

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 Obiettivo del progetto (Objective)

'Although the rate of food contamination with Listeria monocytogenes is low, the mortality rate that is caused by this microorganism is high, and for this reason, it is placed on the top of the list of pathogens of concern for the public health and consequently for the food industry. L. monocytogenes has emerged as a food-borne pathogen the last decades, due to changes in food processing, consumer habits and the demand for minimally processed foods. The molecular mechanism of virulence has gained a lot of attention and many steps of this complex process have been elucidated to various levels. All L. monocytogenes strains found in foods should be considered to be pathogenic. However, the relative virulence of individual L. monocytogenes isolates can vary substantially. The genetic basis underlying these virulence differences is not yet understood. Differences in gene content exist between strains of different serovars and origins. Differences among strains could also be due to different gene expression/regulation of the core genes of the microorganism. The ability to rapidly determine the pathogenic potential of L. monocytogenes strains is integral to the control and prevention campaign against listeriosis. Throughout the years, different approaches have been employed to assess virulence: in vivo bioassays, in vitro cell assays and targeting virulence-associated proteins and genes. However, these methods have disadvantages such as the need for laboratory animals (bioassays) and the time constraints. Furthermore, targeting virulence genes gives only an indication of the virulence potential of strains. Nowadays, powerful alternatives such as microarrays and reverse transcriptional quantitative polymerase chain reaction (RT-qPCR) are available that can assist in the definition of the virulence potential of L. monocyotogenes strains by the means of modelling.'