DORIAN

Developmental Origins of Healthy and Unhealthy Ageing: The Role of Maternal Obesity

Coordinatore	CONSIGLIO NAZIONALE DELLE RICERCHE    more  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Michela Cognome: Rial Email: send email Telefono: +39 050 3152101 Fax: +39 050 315 2095
Nazionalità Coordinatore	Italy [IT]
Sito del progetto	http://www.dorian-fp7.eu/
Totale costo	3˙863˙873 €
EC contributo	2˙999˙973 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2014-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Michela Cognome: Rial Email: send email Telefono: +39 050 3152101 Fax: +39 050 315 2095	IT (ROMA)	coordinator	799˙994.00
2	SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF  Organization address address: TOPELIUSGATAN 20 city: HELSINGFORS postcode: 250 contact info Titolo: Mr. Nome: Christer Cognome: Holmström Email: send email Telefono: +358 9 31 5000 Fax: +358 9 3155101	FI (HELSINGFORS)	participant	600˙000.00
3	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 4028	UK (EDINBURGH)	participant	350˙000.00
4	TURUN YLIOPISTO  Organization address address: YLIOPISTONMAKI city: TURUN YLIOPISTO postcode: 20014 contact info Titolo: Dr. Nome: Eliisa Cognome: Särkilahti Email: send email Telefono: +358 2 3336155 Fax: +358 2 3336363	FI (TURUN YLIOPISTO)	participant	349˙993.00
5	BIOMOL-INFORMATICS SL  Organization address address: CALLE FARADAY -Parque Cientifico- 7 city: MADRID postcode: 28049 contact info Titolo: Ms. Nome: Milagros Cognome: Ruiz Del Peso Email: send email Telefono: +34 918279767 Fax: +34 911880756	ES (MADRID)	participant	210˙000.00
6	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mr. Nome: Hartmut Cognome: Lingner Email: send email Telefono: +49 89 30622330 Fax: +49 89 30622372	DE (MUENCHEN)	participant	200˙000.00
7	ISTITUTO SUPERIORE DI SANITA  Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 contact info Titolo: Dr. Nome: Rosa Cognome: Martoccia Email: send email Telefono: +39 06 49902688 Fax: +39 06 49903007	IT (ROMA)	participant	199˙986.00
8	GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O  Organization address address: Oskar-von-Miller-Ring 29 city: MUENCHEN postcode: 80333 contact info Titolo: Ms. Nome: Birgit Cognome: Fuchs Email: send email Telefono: +49 89 28810414 Fax: +49 89 28810420	DE (MUENCHEN)	participant	195˙000.00
9	European Association for the Study of Obesity  Organization address address: High Street 113-119 city: Hampton Hill postcode: TW12 1NJ contact info Titolo: Mr. Nome: Euan Cognome: Woodward Email: send email Telefono: +44 20 87832256 Fax: +44 20 8979 6700	UK (Hampton Hill)	participant	80˙000.00
10	Mouvement Mondial des Meres - Europe  Organization address address: Avenue Nestor Plissart 8 city: Bruxelles postcode: 1040 contact info Titolo: Ms. Nome: Marie-Claude Cognome: Hayoit De Termicourt Email: send email Telefono: +32 475 33 61 35	BE (Bruxelles)	participant	15˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'Europe has the highest proportion of elderly people in the world. Cardiovascular disease (CVD), type 2 diabetes (T2D), sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Obesity is a main health concern in the world. In the EU one-third of women of reproductive age are overweight and 20% are obese, a prevalence predicted to double in the next decade. There is growing evidence that maternal obesity increases the long term risk of CVD, T2D and neurodegenerative morbidity in the offspring. This project will clarify if and to what extent maternal obesity leads to premature and unhealthy ageing, by causing early, i.e. pre-/perinatal metabolic and genetic vulnerability, starting from insulin resistance and glucocorticoid exposure, leading to oxidative-stress, telomere/DNA damage, epigenetic changes, interacting with genetic and environmental variability, resulting in altered gene expression/repair, and ultimately in disease during life and pathological ageing. We will investigate the postulated mechanisms during pregnancy and development, their life long consequences in animal models and in large human cohorts followed from prenatal life until ageing, and the possibility to intervene when the condition is still reversible. Surrogate markers to estimate early risk and monitor progression-regression will be defined. This project will comprehensively address the expected impacts listed in the work programme HEALTH.2011.2.2.2-2 targeting the improvement of health and healthy ageing of a broad/broadening European population. The participation of a research intensive SME and European NGOs guarantees success in biomarker discovery-innovation and in dissemination-public preventive programs. The scientific excellence and complementariness of the partners and the relevance of the target health problem will make a highly significant impact on the European policy and research in this area.'

Introduzione (Teaser)

Comprehending how maternal obesity could influence offspring health could improve the overall health of the European population. For this purpose, European scientists have set out to identify which early developmental factors determine our health and ageing.