HIPAD

"High-Density Peptide MicroArrays and high-throughput, label-free detection of peptides, modifications and interactions"

Coordinatore	KOBENHAVNS UNIVERSITET    more  Organization address postcode: 1017 contact info Titolo: Mr. Nome: Ivan Cognome: Kristoffersen Email: send email Telefono: +45 35322626 Fax: +45 35324612
Nazionalità Coordinatore	Denmark [DK]
Totale costo	6˙382˙419 €
EC contributo	4˙823˙014 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET	DK	coordinator	717˙609.90
2	SCHAFER -N APS  Organization address address: KYSTVEJ 6 city: HUMLEBAEK postcode: 3050 contact info Titolo: Dr. Nome: Claus Schafer Cognome: Nielsen Email: send email Telefono: +45 3927 3800 Fax: +45 3927 3801	DK (HUMLEBAEK)	participant	1˙061˙166.80
3	PLASMORE SRL  Organization address address: VIA G DELEDDA 4 city: RANCO VA postcode: 21020 contact info Titolo: Dr. Nome: Andrea Cognome: Valsesia Email: send email Telefono: 393470000000	IT (RANCO VA)	participant	697˙860.00
4	IMABIOTECH  Organization address address: "CITE SCIENTIFIQUE BATIMENT SN 3, 1 ER ETAGE" city: VILLENEUVE D ASCQ postcode: 59655 contact info Titolo: Dr. Nome: Jonathan Cognome: Stauber Email: send email Telefono: +33 632940351	FR (VILLENEUVE D ASCQ)	participant	658˙300.00
5	UNIVERSITY OF BATH  Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY contact info Titolo: Ms. Nome: Hazel Cognome: Wallis Email: send email Telefono: +44 1225 386822 Fax: +44 1225 383276	UK (BATH)	participant	444˙300.80
6	DANMARKS TEKNISKE UNIVERSITET  Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Mr. Nome: Jesper Cognome: Thorsgaard Email: send email Telefono: +45 51 15 74 23 Fax: +45 45 93 15 85	DK (KONGENS LYNGBY)	participant	316˙547.25
7	JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION  Organization address address: Rue de la Loi 200 city: BRUSSELS postcode: 1049 contact info Titolo: Dr. Nome: Ian Cognome: Formosa Email: send email Telefono: 390333000000	BE (BRUSSELS)	participant	316˙510.80
8	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Ms. Nome: Liz Cognome: Fay Email: send email Telefono: 441613000000	UK (MANCHESTER)	participant	314˙070.00
9	BRUKER DALTONIK GMBH  Organization address address: Fahrenheitstrasse 4 city: BREMEN postcode: 28359 contact info Titolo: Ms. Nome: Tanja Cognome: Lorek Email: send email Telefono: +49 42122051394	DE (BREMEN)	participant	148˙817.50
10	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Mr. Nome: Walter Cognome: Krause Email: send email Telefono: +49 89 12052713	DE (MUENCHEN)	participant	147˙831.00

Mappa

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 Obiettivo del progetto (Objective)

'Proteins are extremely malleable building blocks of life involved in all aspects of biology. Many diseases are caused by proteins aberrations, and proteins are frequent targets of intervention. Mapping all proteins and their functions are expected to yield pervasive medical and biotechnological benefits. However, even the most comprehensive and high-throughput proteins discovery technologies are seriously challenged by the extreme diversity and low abundance of many proteome components; a problem, compounded by the lack of affinity reagents and validated probes for sample preparation and identification. Our concept is that shorter protein fragments, or peptides, may offer solutions to many of these problems as peptides may represent or mimic proteins. Using in situ solid-phase peptide synthesis, computerized photolithography and novel photochemistry, we have recently generated peptide microarrays of up to 2 million addressable peptides. This unprecedented high-density and high-content peptide microarray technology could make inroads into the kind of high-throughput analysis needed to address the entire human proteome. Here, we aim to exploit this potential by using and improving three different, yet complementary, label-free detection technologies allowing sensitive, high-resolution determinations of the identity, quality and/or modification of individual members of a peptide microarray, and real-time monitoring of any interacting molecular receptor. We will also develop peptides as rapid, specific, and renewable affinity reagents for complex sample preparation, and develop peptides as probes and complex biosensors. Three SME’s constitute the backbone of this collaboration, receiving 50% of the budget, and enjoying significant opportunities from the booming protein/peptide microarray market. Furthermore, solutions to these unmet needs of proteomics are believed to have incalculable benefits for European health, innovativeness and competiveness.'