INNOVALIV

Innovative strategies to generate human hepatocytes for treatment of metabolic Liver diseases: Tools for personalized cell therapy

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)    more  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Nadia Cognome: El-Hamdi Email: send email Telefono: +33 1 49 59 53 60 Fax: +33 1 49 59 18 20
Nazionalità Coordinatore	France [FR]
Totale costo	7˙682˙012 €
EC contributo	5˙884˙171 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-12-01   -   2014-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Nadia Cognome: El-Hamdi Email: send email Telefono: +33 1 49 59 53 60 Fax: +33 1 49 59 18 20	FR (PARIS)	coordinator	962˙084.00
2	CELLGENIX GMBH  Organization address address: AM FLUGHAFEN 16 city: FREIBURG postcode: 79108 contact info Titolo: Dr. Nome: Bernd Cognome: Leistler Email: send email Telefono: +49 761 8888 9205 Fax: +49 761 8888 9800	DE (FREIBURG)	participant	1˙774˙289.00
3	TAKARA BIO EUROPE AB  Organization address address: ARVID WALLGRENS BACKE 20 city: GOETEBORG postcode: 413 46 contact info Titolo: Ms. Nome: Ulrika Cognome: Törn Lausten-Thomsen Email: send email Telefono: +46 31 758 09 11 Fax: +46 31 758 09 10	SE (GOETEBORG)	participant	1˙445˙201.00
4	FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA  Organization address address: AVENIDA CAMPANAR 21 city: VALENCIA postcode: 46009 contact info Titolo: Ms. Nome: Sabrina Cognome: Femenia Email: send email Telefono: +34 971973452 Fax: +34 963494416	ES (VALENCIA)	participant	578˙500.00
5	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Edwards Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	participant	504˙734.00
6	INSERM - TRANSFERT SA  Organization address address: Rue Watt 7 city: PARIS postcode: 75013 contact info Titolo: Mr. Nome: Louis Cognome: Jammayrac Email: send email Telefono: +33 1 55030101 Fax: +33 1 55030160	FR (PARIS)	participant	364˙652.00
7	FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE  Organization address address: CALLE EDUARDO PRIMO YUFERA 3 city: VALENCIA postcode: 46012 contact info Titolo: Ms. Nome: Ana Cognome: Alvarez Email: send email Telefono: +34 96 3289680 Fax: +34 96 3289701	ES (VALENCIA)	participant	254˙711.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Transplantation of donor hepatocytes has become an alternative to liver transplantation for the treatment of liver diseases. However, in addition to the complication imposed by severe shortage of donor livers, adult hepatocytes cannot be expanded in vitro. Autologous transplantation of genetically corrected hepatocytes represents another strategy as it circumvents the need for immunosuppression but this approach requires removal of 20% of the liver to isolate hepatocytes, which is not devoid of risks in patients with metabolic diseases. Therefore, there is a critical need to explore the potential human stem cells such as human Embryonic Stem (hES) cells to generate sufficient quantities of functional human hepatocytes. However, the production of safe and fully functional, human hepatocytes from hES cells under GMP conditions for clinical applications remains to be achieved. The general scientific objectives of this proposal are: - to develop scale-up procedures for hES cells and to produce GMP-grade tissue culture reagents that will facilitate large-scale differentiation of hES cells to hepatocytes. InnovaLiv aims to provide the EU healthcare system with a renewable and reliable source of functional clinical-grade hepatocytes generated from EU hES cells lines. Rigorous standards to ensure the safety and quality of these cells will be developed. The GMP-compliant hepatocytes will be prepared as a prototype therapy aiming at treating one patient on the basis of a compasive use protocol. - to provide proof-of-principle that defective hepatic function associated with inherited disorders (Familial Hypercholesterolemia, Hemophilia B, Crigler-Najjar) can be regenerated by correction of the deficiency in patient-specific iPS cells using integration-targeted lentiviral vectors to express the therapeutic cDNAs. Commercialization of novel products such as GMP-grade cells and cell culture tools will be performed by two partner SMEs that will assume leading roles in InnovaLiv.'

Introduzione (Teaser)

Cell therapy for chronic liver diseases has attracted much attention as a promising alternative to organ transplantation. A European consortium is investigating various stem cell sources to derive clinically suitable hepatocytes.