BRAINAGE
Impact of Prenatal Stress on BRAIN AGEing
| Coordinatore | Universitätsklinikum Jena
Organization address
city: Jena contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.brain-age.eu/ |
| Totale costo | 3˙880˙676 € |
| EC contributo | 2˙998˙420 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2011-two-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-03-01 - 2017-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
Nome Ente NON disponibile
Organization address
city: Jena contact info |
DE (Jena) | coordinator | 1˙076˙295.60 |
| 2 |
THE UNIVERSITY OF TEXAS SYSTEM
Organization address
address: COLORADO STREET 601 contact info |
US (AUSTIN) | participant | 372˙800.40 |
| 3 |
Academisch Medisch Centrum bij de Universiteit van Amsterdam
Organization address
address: MEIBERGDREEF 9 contact info |
NL (AMSTERDAM) | participant | 355˙542.40 |
| 4 |
BIOCRATES LIFE SCIENCES AG
Organization address
address: EDUARD BODEM GASSE 8 1 STOCK contact info |
AT (Innsbruck) | participant | 303˙585.60 |
| 5 |
LEIBNIZ-INSTITUT FUR ALTERSFORSCHUNG - FRITZ-LIPMANN-INSTITUT E.V.
Organization address
address: BEUTENBERGSTRASSE 11 contact info |
DE (JENA) | participant | 269˙544.00 |
| 6 |
STICHTING KATHOLIEKE UNIVERSITEIT BRABANT UNIVERSITEIT VAN TILBURG
Organization address
address: Warandelaan 2 contact info |
NL (TILBURG) | participant | 217˙279.20 |
| 7 |
UNIVERSITAET ULM
Organization address
address: HELMHOLTZSTRASSE 16 contact info |
DE (ULM) | participant | 216˙144.00 |
| 8 |
LIFE LENGTH SL
Organization address
address: CALLE AGUSTIN DE BETANCOURT 21 contact info |
ES (MADRID) | participant | 115˙800.00 |
| 9 |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address
address: Oude Markt 13 contact info |
BE (LEUVEN) | participant | 71˙428.80 |
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Obiettivo del progetto (Objective)
'Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ageing; (2) this predisposes to age-associated brain diseases including cognitive decline and stroke; (3) epigenetic changes affecting glucocorticoid receptor (GR) sensitivity, altered autonomic nervous system (ANS) reactivity and cerebrovascular tone are important mediators of these processes, (4) these changes represent targets for diagnosis and therapeutic interventions. Our consortium has unique access to well-defined human and non-human primate cohorts (age range 25-115 y equivalents) that have been exposed to different types of prenatal stress. For experimental analysis of mechanisms of prenatal programming, we apply innovative techniques to characterize brain ageing, namely MRI based volumetry, non-linear analysis of EEG and ANS, advanced molecular techniques including epigenetics and metabolomics and neuropsychological and behavioral tests. Human subjects, non-human primates and rodents (including transgenic models) exposed to maternal stress, glucocorticoids or undernutrition are examined in order to: (1) determine structural (MRI based volumetry) and functional (metabolomics, brain function, cerebrovascular tone) indicators of brain age, (2) relate them to susceptibility to stroke and cognitive decline, (3) determine to what extent GR resistance, stress sensitivity, and cerebrovascular contractility mediate premature brain ageing and disease susceptibility; and, (4) dissect mechanisms and pharmacological interventions relevant for aged subjects. Data from the study allow to identify subjects at risk for premature brain ageing and to initiate interventional therapy.'