DART-MS CHALLENGES

Direct Analysis in Real Time mass spectrometry: meeting the challenges in qualitative and quantitative analysis

Coordinatore	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN    more  Organization address address: Ludwigstrasse 23 city: GIESSEN postcode: 35390 contact info Titolo: Dr. Nome: Christian Cognome: Veldman Email: send email Telefono: 496420000000 Fax: 496420000000
Nazionalità Coordinatore	Germany [DE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-05-16   -   2016-05-15

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN  Organization address address: Ludwigstrasse 23 city: GIESSEN postcode: 35390 contact info Titolo: Dr. Nome: Christian Cognome: Veldman Email: send email Telefono: 496420000000 Fax: 496420000000	DE (GIESSEN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Direct Analysis in Real Time mass spectrometry (DART-MS) was reported first in 2005 and gained a wide attention due to the possibility for direct mass spectrometric analysis of solids and liquids, often without any sample preparation and chromatographic separation. According to some opinions, it could be nominated for the next Nobel prize in mass spectrometry. However, until now the general methodology is not yet established and a lot of challenges are to be met before DART-MS will really be considered as a full-scale and powerful analytical method. The available publications contain limited and contradictory data. A lot of capabilities and potentially attractive applications of DART-MS have not been studied or even demonstrated yet. The purpose of the project is the development of the analytical methodology of DART-MS and the establishment of new approaches for analysis of complex samples, based on DART-MS and its hyphenations with different sampling techniques and planar chromatography. It will include detailed studies on optimization of DART instrumental and experimental conditions to provide the best achievable analytical characteristics. The special attention will be given to the coupling of planar chromatography with DART-MS. Possibilities for DART-MS Imaging of small molecule distributions on different surfaces and for analysis of the dried spots of biological liquids on a carrier will be investigated for the first time. Also the following new DART-MS application areas will be studied: fast qualitative and quantitative screening of antibiotics in different food and environmental samples; analysis of bee products (honey, propolis); and identification of aroma compounds and undesired components in foods, drinks and commodities. The implementation of the current project will establish DART mass spectrometry as a powerful full-scale analytical method and will expand the areas of its use due to the hyphenation with different planar chromatography approaches.'