BILOBA

Bloch electromagnetic surface wave Bio-sensors for early cancer diagnosis

Coordinatore	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA    more  Organization address address: Via Antonio Scarpa 16 city: Roma postcode: 161 contact info Titolo: Mrs. Nome: Alessandra Cognome: Pelorosso Email: send email Telefono: +39 06 49916490 Fax: +39 06 44240183
Nazionalità Coordinatore	Italy [IT]
Totale costo	4˙731˙524 €
EC contributo	3˙600˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2011-8
Funding Scheme	CP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2015-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA  Organization address address: Via Antonio Scarpa 16 city: Roma postcode: 161 contact info Titolo: Mrs. Nome: Alessandra Cognome: Pelorosso Email: send email Telefono: +39 06 49916490 Fax: +39 06 44240183	IT (Roma)	coordinator	0.00
2	BioTray SAS  Organization address address: Jean Baldassini 24 city: Lyon postcode: 69007 contact info Titolo: Mr. Nome: Raphael Cognome: ANASTHASE Email: send email Telefono: +33 4 27021581	FR (Lyon)	participant	0.00
3	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUNCHEN postcode: 80686 contact info Titolo: Mr. Nome: Maximilian Cognome: Steiert Email: send email Telefono: +49 89 12052721	DE (MUNCHEN)	participant	0.00
4	HORIBA JOBIN YVON S.A.S.  Organization address address: Rue du Canal 16-18 city: LONGJUMEAU postcode: 91160 contact info Titolo: Mr. Nome: Olivier Cognome: Rogerieux Email: send email Telefono: +33 01 64541300	FR (LONGJUMEAU)	participant	0.00
5	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: Exhibition Road, South Kensington Campus city: LONDON postcode: SW7 2AZ contact info Titolo: Mr. Nome: Shaun Cognome: Power Email: send email Telefono: +44 207 594 8773 Fax: +44 207 594 8609	UK (LONDON)	participant	0.00
6	KDS RADEBERGER PRAZISIONS-, FORMEN- UND WERKZEUGBAU GMBH  Organization address address: RICHARD-THIEME-STRASSE 6 city: GROSSROHRSDORF postcode: 1900 contact info Titolo: Mr. Nome: Thomas Cognome: Schubert Email: send email Telefono: +49 35952 33233	DE (GROSSROHRSDORF)	participant	0.00
7	LABOR SRL  Organization address address: VIA DELLA SCROFA 117 city: ROMA postcode: 186 contact info Titolo: Dr. Nome: Cristina Cognome: Torrisi Email: send email Telefono: 390640000000 Fax: 390640000000	IT (ROMA)	participant	0.00
8	POLITECNICO DI TORINO  Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 contact info Titolo: Dr. Nome: Claudia Cognome: Roveglia Email: send email Telefono: +39 011 564 4617	IT (TORINO)	participant	0.00
9	UNIVERSITA DEGLI STUDI DI TORINO  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Mrs. Nome: Daniela Cognome: Pegoraro Email: send email Telefono: +39 011 9933614 Fax: +39 011 99332524	IT (TORINO)	participant	0.00

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 Obiettivo del progetto (Objective)

BILOBA aims to develop and pre-clinically validate a multifunctional point-of-care platform capable of performing real-time cancer biomarker detection in a tandem configuration. The configuration exploits a label-free detection based on the resonance shifts, and the spectral analysis of enhanced fluorescence emitted by biomolecules immobilized on the surface. Utilizing both labeled and label-free analysis on one sensor increases the sensitivity and the reliability of optically read-out surface bound assays.nThe standard optical label-free detection is the surface plasmon resonance (SPR) method. Its sensitivity suffers from the strong absorption of waves bound to the metal surface. Here, a similar concept, already at the proof of principle stage, will be advantageously implemented by applying the unique properties of Bloch Surface Waves (BSW) sustained on 1D Photonic Crystals (1DPC). Therein, a surface wave without absorption is excited, giving rise to an enormous narrowing of resonances and an associated increase in sensitivity. Furthermore, fluorescence enhancement due to near field effects will be exploited. By engineering the BSW dispersion both detection schemes will be combined.nThe goal of the project is to explore, design, and set-up BSW systems optimized for analytical sensing, and develop a corresponding analytical instrument. Immobilization protocols and biochemical assays have to be established for optimizing the binding site surface density and for detecting the target biomarkers. The development of a sophisticated, robust fluidic system to ensure a high signal-to-noise ratio even in the case of lowest analyte concentrations accompanies this work.nThe results will be applied to early cancer biomarker analysis by validating the project's results in pre-clinical tests. The target application is the detection of Angiopoetin1 and Vascular Endothelial Growth Factor with these proteins being indicative of angiogenesis associated to human cancer progression.