ANION_CAGES

Dynamic Constitutional Chemistry for the Preparation of Receptors for Anions of Biological Interest

Coordinatore	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS    more  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Alberto Cognome: Sereno Alvarez Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 8913
Nazionalità Coordinatore	Spain [ES]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Alberto Cognome: Sereno Alvarez Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 8913	ES (MADRID)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'From chloride to DNA, over 75% of the cofactors and bio-molecules have negative charge at physiological pH. However, efficient synthetic receptors for anionic entities in aqueous solution have attracted lesser attention than ligands for cationic or neutral species. The intrinsic physicochemical problems of anion binding and the molecular diversity of anionic species have often hampered this research field. In this project, the identification and synthesis of new molecular receptors for anions with biological relevance is proposed. To this aim, we will use a constitutional dynamic chemistry approach, a conceptually new methodology based on the molecular evolution idea. Thus, we will prepare a dynamic library of components interconnected through exchange by chemical equilibriums. These building blocks will bear a molecular recognition moiety able to bind anions, and the required functional group(s) for the establishment of a covalent bond under reversible conditions. In the presence of the target entity (an anionic template), the dynamic system will evolve to efficiently interact with the template and the best binder will be amplified and identified. As the building blocks, we will use peptide-like molecular architectures, since they can bear different potential anion binding functions (amide, ammonium, etc…), show large molecular and structural diversity and, in general, display good biological tolerance. Additionally, their synthetic, isolation and characterization procedures are quite straightforward. Using this rationale with anionic templates of biological importance, this methodology will allow us to synthesize new receptors of biologically interesting molecules with increased binding abilities, which will be finally tested for the corresponding biological functions. Therefore, if successful, this project will mean an important methodological breakthrough in anion recognition chemistry.'