COMBI-BIO

Development of COMBInatorial BIOmarkers for subclinical atherosclerosis

Coordinatore	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE    more  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Palalic Email: send email Telefono: +44 20 7594 6265
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	3˙878˙715 €
EC contributo	2˙964˙695 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2014-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Palalic Email: send email Telefono: +44 20 7594 6265	UK (LONDON)	coordinator	693˙398.44
2	METABOMETRIX LTD  Organization address address: PRINCE CONSORT ROAD city: LONDON postcode: SW7 2BP contact info Titolo: Mrs. Nome: Judy Cognome: Collingham Email: send email Telefono: +4420 7594 6595	UK (LONDON)	participant	1˙769˙999.40
3	NORTHWESTERN UNIVERSITY  Organization address address: Clark Street 633 city: "EVANSTON, ILLINOIS" postcode: 60208 contact info Titolo: Prof. Nome: Philip Cognome: Greenland Email: send email Telefono: 13125031879	US ("EVANSTON, ILLINOIS")	participant	148˙837.00
4	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM  Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Prof. Nome: Albert Cognome: Hofman Email: send email Telefono: +31 10 704 3488 Fax: +31 10 704 4657	NL (ROTTERDAM)	participant	146˙887.00
5	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Jürgen Cognome: Ertel Email: send email Telefono: +49 89 3187 3022	DE (MUENCHEN)	participant	110˙287.00
6	UNIVERSITY OF IOANNINA  Organization address address: "LEOFOROS STAVROS S NIARCHOS, PANEPISTIMIOUPOLI IOANNINON" city: IOANNINA postcode: 45110 contact info Titolo: Prof. Nome: John Cognome: Ioannidis Email: send email Telefono: +32 651007606	EL (IOANNINA)	participant	95˙287.00

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 Obiettivo del progetto (Objective)

'Systems biology involves the analysis of relationships among the elements in a system, viewed as an integrated and interacting network of genes, proteins and biochemical reactions. We have pioneered the use of metabolic profiling and the metabolome-wide association study (MWAS) approach, involving high-throughput spectroscopic screening, to capture comprehensive data on a range of exposures affecting disease risk from genetic, lifestyle, gut microbial and xenobiotic sources. Cardiovascular disease is the leading cause of death worldwide. It is a late manifestation of the pathophysiological processes leading to development of atherosclerosis, starting early in life. There is urgent clinical need to identify predictive combinatorial biomarkers for subclinical atherosclerosis, to allow preventive/treatment strategies to be instituted early in the disease process. Our proposal brings together leaders in metabolic profiling and computational medicine for analysis of multi-omics data, and leading European/US prospective cohorts with subclinical atherosclerosis measurements. We propose to apply untargeted metabolic profiling using both proton Nuclear Magnetic Resonance spectroscopy (1H NMR) and Mass Spectrometry (MS) to discover novel biomarkers for subclinical atherosclerosis in stored serum samples from 4,000 people, with validation in stored samples from a further 4,000 people. We will develop and apply methods for investigating cross-platform (NMR, MS) and multi-omics (genome-wide, metabolome-wide) relationships to gain better understanding of underlying biochemical connectivities and pathways. For identified/validated novel and established/emerging biomarkers, we will develop a predictive combinatorial set of biomarkers and risk scores for subclinical atherosclerosis. This research should lead to identification of a novel set of combinatorial biomarkers, with potential to develop low-cost tests for subclinical atherosclerosis, for translation into clinical practice.'

Introduzione (Teaser)

The leading cause of death, cardiovascular disease is a late manifestation of atherosclerosis. An EU study identified predictive biomarkers for subclinical atherosclerosis to empower the development of early preventive and treatment strategies.