COSMIC

Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial

Coordinatore	HET KONINKLIJK INSTITUUT VOOR DE TROPEN    more  Organization address address: "Mauritskade, 63" city: AMSTERDAM postcode: 1092 AD contact info Titolo: Dr. Nome: Hendricus Cognome: Schallig Email: send email Telefono: 31205665447 Fax: 316971841
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.cosmicmalaria.eu/
Totale costo	3˙944˙701 €
EC contributo	2˙997˙218 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-09-01   -   2016-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HET KONINKLIJK INSTITUUT VOOR DE TROPEN  Organization address address: "Mauritskade, 63" city: AMSTERDAM postcode: 1092 AD contact info Titolo: Dr. Nome: Hendricus Cognome: Schallig Email: send email Telefono: 31205665447 Fax: 316971841	NL (AMSTERDAM)	coordinator	468˙815.40
2	CENTRE MURAZ  Organization address address: Avenue Mamadou Konate city: BOBO-DIOULASSO postcode: NA contact info Titolo: Ms. Nome: Ida Cognome: Ouédraogo Email: send email Telefono: +226 7 0346354	BF (BOBO-DIOULASSO)	participant	694˙719.00
3	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Mr. Nome: Dembo Cognome: Kanteh Email: send email Telefono: 2204495917	UK (SWINDON)	participant	619˙592.00
4	Ministere de la sante  Organization address address: n/a city: Cotonou postcode: 06 BP 3029 contact info Titolo: Dr. Nome: Alain Cognome: Nahum Email: send email Telefono: +229 97 592920	BJ (Cotonou)	participant	566˙998.00
5	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE  Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 contact info Titolo: Ms. Nome: Eva Cognome: Mostmans Email: send email Telefono: +32 3 2470722 Fax: +32 3 2476359	BE (ANTWERPEN)	participant	260˙360.40
6	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Tatjana Palalic Email: send email Telefono: +44 207 5946265	UK (LONDON)	participant	199˙958.00
7	WORLD HEALTH ORGANIZATION.  Organization address address: Avenue Appia 20 city: GENEVE postcode: 1211 contact info Titolo: Dr. Nome: Melba Cognome: Gomes Email: send email Telefono: +41 22 7913813	CH (GENEVE)	participant	186˙775.20

Mappa

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 Obiettivo del progetto (Objective)

'Pregnant women are very susceptible to malaria infection and Malaria in Pregnancy (MiP) is a major cause of maternal anaemia and low birth weight (LBW) that leads to infant mortality, poor growth and development. In low transmission areas, malaria can become severe, resulting in maternal and foetal death. In sub-Saharan Africa (SSA) MiP is responsible for 8–14% of LBW, 3–8% of infant deaths, higher risk of post-partum haemorrhage and >10,000 maternal deaths/year. Prevention like, bed nets and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp/SP), is cheap and cost-effective, but coverage achieved by these interventions is low. Therefore, we propose Community Health Workers (CHW) to implement scheduled intermittent screening at community level with RDT of pregnant women and if positive treat with anti-malarials (SST). In addition CHWs will encourage pregnant women to attend antenatal clinics (ANC) for other pregnancy-targeted interventions and IPTp/SP, thereby improving its coverage. This approach combines existing IPTp/SP with SST at village level as an extension of Home based management of malaria (HMM). This low cost (based on existing practice) and simple (diagnosis by RDTs) intervention improves maternal and newborn health and capitalise on an already existing intervention (HMM). The aim of this proposal is to determine the added value (as compared to IPTp/SP alone implemented in health facilities) of community SST of pregnant women implemented through the CHW involved in HMM. Objectives are: 1) Identify bottlenecks for implementation by CHW involved in HMM of SST; 2) determine impact of introducing SST in pregnancy on quality of HMM; 3) determine the impact of SST on ANC attendance and IPTp/SP coverage; 4) determine the impact of SST on LBW, anaemia and placenta malaria; 5) estimate cost-effectiveness of SST as compared to IPTp/SP alone and 6) formulate recommendations for possible implementation of the intervention.'

Introduzione (Teaser)

Low-cost interventions to manage malaria in resource-poor countries are of paramount importance. With a focus on pregnant women, the scope of the COSMIC initiative is to improve maternal and infant health in malaria-endemic countries.