UCNANOMAT4IPACT

Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy

Coordinatore	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES    more  Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 city: SAN SEBASTIAN postcode: 20009 contact info Titolo: Mr. Nome: Alfonso Cognome: Egaña Email: send email Telefono: 34943005300 Fax: 34943005301
Nazionalità Coordinatore	Spain [ES]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-15   -   2017-01-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES  Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 city: SAN SEBASTIAN postcode: 20009 contact info Titolo: Mr. Nome: Alfonso Cognome: Egaña Email: send email Telefono: 34943005300 Fax: 34943005301	ES (SAN SEBASTIAN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds studied as novel photochemotherapy agents. UCNP-mediated NIR activation will allow overcoming metal complexes’ light absorption limitations, simultaneously achieving considerably higher tissue penetration and preserving photochemical reactivity. Indeed, the rich photochemistry of metal complexes can result in unique cell killing modes, critically important in the development of novel anticancer prodrugs. The project aims at investigating the use of UCNPs in the photoactivation of promising anticancer metal complexes, and more specifically at developing new nanomaterials where these two components are integrated to give a superior prodrug. Anchoring photoactive anticancer coordination compounds on UCNPs can produce materials with optimal photophysical and photochemical properties for chemotherapy. Moreover, the chemical versatility of UCNPs offers opportunity for functionalization with biological vectors, which improve biocompatibility, targeting and selectivity features of these integrated nanomaterials in cells and tissues. Remarkably, UCNPs are also excellent new candidates for multimodal (optical/MRI/PET) bioimaging. Their upconverted luminescence, magnetic resonance relaxivity and radioactivity (ease of 18F-labeling) will serve to visualize fundamental biological events with high spatial resolution, which are key to study the photoactive nanomaterials’ anticancer action as well as for their medical use. All such features combined together have the potential to deliver innovative therapeutic and imaging agents for cancer phototherapy.'