BRAINLEAP
A quantum leap: from a spike-centered brain universe to its underlying synaptic landscape
| Coordinatore | UNIVERSITEIT ANTWERPEN
Organization address
address: PRINSSTRAAT 13 contact info |
| Nazionalità Coordinatore | Belgium [BE] |
| Totale costo | 3˙286˙599 € |
| EC contributo | 2˙478˙350 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2011-C |
| Funding Scheme | CP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-02-01 - 2016-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITEIT ANTWERPEN
Organization address
address: PRINSSTRAAT 13 contact info |
BE (ANTWERPEN) | coordinator | 0.00 |
| 2 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 0.00 |
| 3 |
NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Organization address
address: MARKWIESENSTRASSE 55 contact info |
DE (REUTLINGEN) | participant | 0.00 |
| 4 |
THE HEBREW UNIVERSITY OF JERUSALEM.
Organization address
address: GIVAT RAM CAMPUS contact info |
IL (JERUSALEM) | participant | 0.00 |
| 5 |
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Organization address
address: Piazzale Aldo Moro 5 contact info |
IT (ROMA) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
The richness of high-level cognitive and adaptive properties of the brain is reflected in the complexity of its anatomy and (electro)physiology. At the cellular level, evolution privileged for the central nervous system an analog distributed information storage and encoding, by plastic (graded) synapses and by their continuous temporal and spatial integration into firing rates. Beyond all-or-none action potentials, subthreshold synaptic and membrane electric activity in neurons disclose the details of single-neuron computations, neuronal identity and role, information processing and synaptic readout, as well as history-dependent dynamics of excitability and synaptic efficacy. The long-term experimental access to subthreshold activity of many neurons simultaneously, during behaviour and cognition, is then a requirement for the ultimate understanding of brain functions, its reverse engineering, as well as an unexplored alternative for neuroprosthetics.nProject BRAINLEAP develops a breakthrough, revolutionary technological approach to explore cognition and plasticity in cortical neuronal networks, and preliminary applies it in vitro and in awake behaving rodents and primates. BRAINLEAP will enable simultaneous, long-term, and independent recording and stimulation of the electrical activity from hundreds of individual mammalian neurons, with a quality that in practice matches the intracellular configuration. By allowing one to record (and stimulate) for very long times, synaptic- and action-potentials from individual neurons, in the context of specific sensorimotor integration tasks, the leap we propose might ultimately shift current paradigms and theories, from spike-centred computation to its underlying subthreshold synaptic potentials computation.