ZEBRATECTUM

Anatomical and Functional Dissection of Neural Circuits in the Zebrafish Optic Tectum

 Coordinatore  

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Non specificata
 Totale costo 1˙920˙000 €
 EC contributo 19 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-01-01   -   2017-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Dr.
Nome: Filippo
Cognome: Del Bene
Email: send email
Telefono: 33156246552

FR (PARIS) hostInstitution 1˙920˙000.00
2    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Mrs.
Nome: Corinne
Cognome: Cumin
Email: send email
Telefono: 33156246620
Fax: 33156246627

FR (PARIS) hostInstitution 1˙920˙000.00

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

connectivity    neuronal    inhibitory    functional    analyzing    interneurons    dissect    superficial    tectum    function    vivo    circuits    circuit    tectal    model    sins    imaging    synaptic    cells    visual    neuropil   

 Obiettivo del progetto (Objective)

'The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We plan to examine the formation and function of the visual system in zebrafish larvae using in vivo time-lapse microscopy and state-of-the-art “connectomic” and “optogenetic” approaches to monitor and perturb neuronal activity. We will apply complementary cellular and molecular analyses to dissect this circuit and identify the neuronal substrate of visual behaviors. We will start by analyzing the function, development and connectivity of a newly characterized class of inhibitory interneurons located in the superficial part of the tectal neuropil named SINs (superficial inhibitory interneurons) that I have previously identified. Our work based on functional imaging has placed SINs at the center of a tectal micro-circuit for size tuning of visual stimuli. We will dissect this working model by analyzing the physiological properties of SINs. We also will investigate their development and connectivity at the level of single synapses by imaging these cells in vivo using fluorescent reporters in transgenic animals. We will then study how SINs migrate to their final position in the superficial tectum away from the zone where they are initially generated and how their processes direct tectal synaptic lamina formation. SINs are the only tectal cells expressing Reelin and we will analyze the role of this pathway in tectal development and proper synaptic lamination in the tectal neuropil. Our multidisciplinary approach aims to describe in great detail the formation and function of a neuronal circuit crucial for visual function, establishing this model for neural circuits studies in vertebrates.'

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