MICROSOCIOGENOMYX
Quantifying the roles that evolutionary forces play in shaping genomic and social divergence in natural populations of the cooperative bacterium Myxococcus xanthus
| Coordinatore | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
| Nazionalità Coordinatore | Switzerland [CH] |
| Totale costo | 192˙622 € |
| EC contributo | 192˙622 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2012-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-04-01 - 2015-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | coordinator | 192˙622.20 |
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Obiettivo del progetto (Objective)
'Our understanding of microbial genetic diversity in nature and how it relates to phenotypic divergence is extremely limited, including for social traits like those exhibited by myxobacteria. Relying on next-generation sequencing, the project proposed here seeks to quantify the roles that the forces of evolution play in shaping genomic and social divergence in natural populations of the model cooperative myxobacterium, Myxoccocus xanthus. First, I will use a global and spatially hierarchical collection of natural isolates spanning large metric scales to grasp both total and spatially partitioned genetic diversity in M. xanthus. Second, I will analyze genetic substitution patterns among these natural isolates, and quantify signals of selection and drift under special consideration of a “gold-standard” mutation rate estimate directly inferred from whole genome sequences of a large collection of lab evolved strains of M. xanthus. Third, I will link previously published phenotypic patterns in closely related natural isolates to their whole genome data to infer their underlying molecular mechanisms, and candidate mutations will be tested directly through construction of isogenic clones in the lab. This proposal offers me the excellent opportunity to receive cutting-edge training at one of Europe’s elite universities and will increase my level of scientific maturity and independence. It will also contribute European excellence in applying cutting-edge technologies to conceptually important questions.'