ENAFUNTRAMECAT

Remote Enantioselective Functionalization of C–H bonds in Saturated Nitrogen Heterocycles

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	221˙606 €
EC contributo	221˙606 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2015-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	221˙606.40

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 Obiettivo del progetto (Objective)

'The development of existing and invention of new synthetic methodologies in recent years has greatly facilitated the preparation of molecules that would once have been considered an insurmountable synthetic challenge. Over the past four decades, the synthetic community has witnessed a tremendous upsurge in the field of transition metal-catalyzed C–C and C–Heteroatom bond forming reactions. The field of C(sp2)–H bond functionalization has grown rapidly over the past decade, providing many new and efficient routes for the synthesis of desirable compounds and a plethora of literature is available including a large number of reviews. In contrast, there are only a handful of reports in the literature where C(sp3)–H bond functionalization is efficiently achieved and field remains largely untouched regarding the development of new and efficient methodologies. However, despite the advances in the field of enantioselective reactions, the use of transition metal catalysts with appropriate and effective chiral ligands is still in its infancy. The overall aim of this project is to develop new chemistry to functionalize the beta-carbon of simple heterocyclic compounds like pyrrolidine and piperidine in enantioselective fashion. Finally we will apply the newly developed catalytic enantioselective C–H functionalization in bioactive natural product/drug molecule synthesis.'