TB PROGNOSIS

A progress of tuberculosis and HIV/tuberculosis treatment assessed by fingerprinting of small molecule-biomarkers in patients from Eastern Europe

Coordinatore	UMEA UNIVERSITET    more  Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 contact info Titolo: Dr. Nome: Olena Cognome: Rzhepishevska Email: send email Telefono: 46907851819
Nazionalità Coordinatore	Sweden [SE]
Totale costo	133˙000 €
EC contributo	133˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IRSES
Funding Scheme	MC-IRSES
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-04-01   -   2017-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UMEA UNIVERSITET  Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 contact info Titolo: Dr. Nome: Olena Cognome: Rzhepishevska Email: send email Telefono: 46907851819	SE (UMEA)	coordinator	87˙400.00
2	INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL  Organization address address: Carretera de Canyet s/n city: BADALONA BARCELONA postcode: 8916 contact info Titolo: Dr. Nome: Cristina Cognome: Prat-Aymerich Email: send email Telefono: 34934978894	ES (BADALONA BARCELONA)	participant	45˙600.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'A dramatically high incidence of multidrug-resistant (MDR) and extended drug resistant (XDR) tuberculosis (TB) was reported in WHO European Region. Countries in Eastern Europe still fail to control TB and in, for example, Ukraine, a number of new TB cases is as high as 100-299 per 100 000 (data for 2010). TB is often accompanied by HIV on this territory. In EU countries, patients with MDR and XDR-TB recover with the efficiency of only 32%. For successful control of TB, quick diagnosis is among most important factors. In low-income countries, TB diagnostics is restricted mainly to clinical manifestations and sputum smear microscopy. TB clinical symptoms are often obscured in HIV positive individuals and sputum smear test detects only up to 60% of TB cases. Modern more efficient methods are not affordable. Furthermore, there are few tools to judge the efficiency of a certain therapy in already confirmed TB cases. We hypothesize that cheaper and quicker detection of TB is possible as well as assessment of the treatment progress over the time. It could be done through measurement of small molecule biomarkers in body fluids of the patients. A network has been created between Umea University, Sweden, Metchnikov’s University/TB Clinics, Ukraine and University Hospital Germans Trias i Pujol, Spain that has access to a modern metabolomics facility and an extensive work experience with TB and chemical analysis of biomedical samples. We propose to collect samples from Ukrainian TB and HIV/TB patients under treatment and analyze them with several chromatographic methods in order to detect relevant biomarkers. We plan also to genotype M.tuberculosis isolates from these patients, monitor possible antibiotic resistance development and evaluate the host response. An array of these methods will help to get a detailed and dynamic clinical description of the cases and assign certain small molecules levels to respective events during treatment of TB, MDR-TB and HIV/TB co-infection.'