NONANTIRES
Non-genetic mechanisms of intrinsic antimicrobial resistance
| Coordinatore | QUEEN'S UNIVERSITY BELFAST
Organization address
address: University Road contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 50˙000 € |
| EC contributo | 50˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2013-CIG |
| Funding Scheme | MC-CIG |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-08-01 - 2015-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
QUEEN'S UNIVERSITY BELFAST
Organization address
address: University Road contact info |
UK (BELFAST) | coordinator | 50˙000.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'NONANTIRES is a groundbreaking project to discover alternative ways for controlling the problem of infection treatment failures due to multidrug antimicrobial resistance. Specifically, my efforts will focus on Gram-negative bacterial opportunistic pathogens that exhibit pan-antibiotic, intrinsic resistance. My team has recently uncovered a novel resistance mechanism based on a cooperative behaviour of bacterial populations that show a heterogeneous response to antibiotics. Highly antibiotic resistant cells in low proportion within a heterogeneous population protect the majority of less resistant cells, as well as less resistant cells of other species. Protection depends on augmented production and release of bacterial molecules that diffuse to the medium and mediate increased antibiotic resistance. My team has obtained proof of principle that inhibiting the synthesis pathways for these molecules confers reduced bacterial resistance to bactericidal antibiotics. NONANTIRES's vision is to establish the molecular mechanism of protection and discover new molecules that will act as antibiotic adjuvants, ultimately providing better therapeutic solutions for combatting multidrug resistant microbes'