MRECB

Molecular Robots Exhibiting Collective Behaviours

 Coordinatore BAR ILAN UNIVERSITY 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Israel [IL]
 Totale costo 1˙496˙063 €
 EC contributo 1˙496˙063 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2018-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY

 Organization address address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900

contact info
Titolo: Dr.
Nome: Ido
Cognome: Bachelet
Email: send email
Telefono: +972 3738 4312
Fax: +972 3738 4312

IL (RAMAT GAN) hostInstitution 1˙496˙063.20
2    BAR ILAN UNIVERSITY

 Organization address address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900

contact info
Titolo: Ms.
Nome: Estelle
Cognome: Waise
Email: send email
Telefono: +972 3 5317439
Fax: +972 3 6353277

IL (RAMAT GAN) hostInstitution 1˙496˙063.20

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

nanorobot    exhibit    molecules    spatiotemporal    therapeutic    nanorobots    toxicity    molecular   

 Obiettivo del progetto (Objective)

'Cells carry out biochemical and physiological functions in the body by intricately controlling the position and activity of matter at the nanoscale. In contrast, our ability to exert equivalent spatiotemporal control over therapeutic molecules is extremely inadequate. That is the reason why although we have very effective therapeutics, their use is often limited by excess toxicity and adverse effects.

We have recently described an autonomous, logic-guided DNA origami nanorobot, capable of transporting molecular payloads between selected points of origin and target, and demonstrated its selectivity and efficacy in inducing tumor cell apoptosis.

Here, we propose to create nanorobots that can be programmed to exhibit collective behaviours. This will provide unprecedented, nearly absolute spatiotemporal control over many therapeutic molecules simultaneously. Using the molecular equivalents of computer programs, which we describe here, these nanorobots will be able to communicate with each other, coordinate timing of activity, form meta-structures, exhibit quorum-sensing capabilities and emulate logical operations using biological cues as bits.

This proposal describes nanorobot design and control, and shows how the nanorobots can be modified to exhibit improved pharmacokinetic performance with negligible immunogenicity and toxicity. This technology could revolutionize therapeutic paradigms and procedures, along with other aspects of current medicine.'

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