#	Pagina
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ECAP

Genetic/epigenetic basis of ethnic differences in cancer predisposition

Coordinatore	UNIVERSITE DE LAUSANNE Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	2˙495˙425 €
EC contributo	2˙495˙425 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-ADG
Funding Scheme	ERC-AG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-02-01 - 2019-01-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE LAUSANNE Organization address city: LAUSANNE postcode: 1015 contact info Titolo: Ms. Nome: Natasa Cognome: Jovanovic Email: send email Telefono: +41 21 6925708 Fax: +41 21 6925705	CH (LAUSANNE)	hostInstitution	2˙495˙425.00
2	UNIVERSITE DE LAUSANNE Organization address city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Gian-Paolo Cognome: Dotto Email: send email Telefono: +41 21 6925714 Fax: +41 21 6925705	CH (LAUSANNE)	hostInstitution	2˙495˙425.00

Mappa

Word cloud

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populations hypothesis keratinocyte clinical p versus dermal capability predisposition network basic differences scc fibroblast epithelial skin differ notch asian caucasian cancer fibroblasts genes keratinocytes goals compartments epigenetic genetic

Obiettivo del progetto (Objective)

'Integration of large scale genetic and epigenetic analysis needs to be coupled with well defined biological hypotheses that can be experimentally tested. This project is aimed at developing a novel integrated approach to understand genetic and epigenetic predisposition to cancer with skin as model system. The Caucasian (West European) and Asian (East Asian) populations differ substantially in their predisposition to skin cancer, specifically Squamous Cell Carcinoma (SCC). The underlying mechanisms are poorly understood. As in other organs, skin SCC results from changes in both epithelial and mesenchymal compartments. We will be focusing on two key gene regulatory networks of cells of the two compartments (keratinocytes and dermal fibroblasts), with a key role in skin SCC. The 'keratinocyte network' has Notch/p53/p63 as key nodes, while the 'dermal fibroblast network' had Notch and AP1 family members. We will pursue two main goals : 1) We will test the hypothesis that a linkage can be established between specific genetic and epigenetic marks in the Caucasian versus Asian populations and differences in expression and function of 'keratinocyte and/or dermal fibroblast network genes'. 2) We will test the hypothesis that keratinocytes and/or dermal fibroblasts of Caucasian versus Asian individuals differ in their tumor yielding capability, and that these differences in cancer forming capability are due to differences in either 'keratinocyte or dermal fibroblast network genes'. The applicant is a world leader in epithelial signaling and cancer biology, and is heading interdisciplinary research efforts that bridge the basic and clinical sciences. Together with his bioinformatician and clinician collaborators, he is in an excellent position to attain the high goals of the proposal. The approach has not been attempted before, is only possible within the frame of an advanced ERC grant, and has substantial basic as well as translational/clinical implications.'