ECAP

Genetic/epigenetic basis of ethnic differences in cancer predisposition

 Coordinatore UNIVERSITE DE LAUSANNE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 2˙495˙425 €
 EC contributo 2˙495˙425 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-02-01   -   2019-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE

 Organization address city: LAUSANNE
postcode: 1015

contact info
Titolo: Ms.
Nome: Natasa
Cognome: Jovanovic
Email: send email
Telefono: +41 21 6925708
Fax: +41 21 6925705

CH (LAUSANNE) hostInstitution 2˙495˙425.00
2    UNIVERSITE DE LAUSANNE

 Organization address city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Gian-Paolo
Cognome: Dotto
Email: send email
Telefono: +41 21 6925714
Fax: +41 21 6925705

CH (LAUSANNE) hostInstitution 2˙495˙425.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

caucasian    populations    epigenetic    asian    capability    skin    fibroblast    goals    keratinocyte    clinical    versus    cancer    hypothesis    genetic    scc    fibroblasts    compartments    basic    predisposition    notch    epithelial    differ    genes    network    dermal    keratinocytes    differences      

 Obiettivo del progetto (Objective)

'Integration of large scale genetic and epigenetic analysis needs to be coupled with well defined biological hypotheses that can be experimentally tested. This project is aimed at developing a novel integrated approach to understand genetic and epigenetic predisposition to cancer with skin as model system. The Caucasian (West European) and Asian (East Asian) populations differ substantially in their predisposition to skin cancer, specifically Squamous Cell Carcinoma (SCC). The underlying mechanisms are poorly understood. As in other organs, skin SCC results from changes in both epithelial and mesenchymal compartments. We will be focusing on two key gene regulatory networks of cells of the two compartments (keratinocytes and dermal fibroblasts), with a key role in skin SCC. The 'keratinocyte network' has Notch/p53/p63 as key nodes, while the 'dermal fibroblast network' had Notch and AP1 family members. We will pursue two main goals : 1) We will test the hypothesis that a linkage can be established between specific genetic and epigenetic marks in the Caucasian versus Asian populations and differences in expression and function of 'keratinocyte and/or dermal fibroblast network genes'. 2) We will test the hypothesis that keratinocytes and/or dermal fibroblasts of Caucasian versus Asian individuals differ in their tumor yielding capability, and that these differences in cancer forming capability are due to differences in either 'keratinocyte or dermal fibroblast network genes'. The applicant is a world leader in epithelial signaling and cancer biology, and is heading interdisciplinary research efforts that bridge the basic and clinical sciences. Together with his bioinformatician and clinician collaborators, he is in an excellent position to attain the high goals of the proposal. The approach has not been attempted before, is only possible within the frame of an advanced ERC grant, and has substantial basic as well as translational/clinical implications.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

ENSEMBLE (2011)

Neural mechanisms for memory retrieval

Read More  

TEXTILE (2009)

An Iconology of the Textile in Art and Architecture

Read More  

3-TOP (2011)

Exploring the physics of 3-dimensional topological insulators

Read More