TORCH

TOR and Cellular Homeostasis

Coordinatore	UNIVERSITE DE GENEVE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	1˙991˙686 €
EC contributo	1˙991˙686 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-CoG
Funding Scheme	ERC-CG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-04-01   -   2019-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Dr. Nome: Alex Cognome: Waehry Email: send email Telefono: 41223797560 Fax: 41223791180	CH (GENEVE)	hostInstitution	1˙991˙686.00
2	UNIVERSITE DE GENEVE  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Robbie Joseph Cognome: Loewith Email: send email Telefono: +41 22 379 6116 Fax: +41 22 379 6868	CH (GENEVE)	hostInstitution	1˙991˙686.00

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 Obiettivo del progetto (Objective)

'The Target Of Rapamycin (TOR) proteins are ser/thr kinases conserved in Eukarya. They nucleate two distinct multiprotein complexes, named TORC1 and TORC2, which regulate many, widely varying, aspects of cell and organism physiology. TOR inhibitors, such as rapamycin and derivatives, are used clinically to treat cancer, cardio-vasculature disease and to prevent organ rejection.

We recently reported that both TORC1/2 are wired in feedback loops, where their downstream cellular effectors are at the same time upstream regulators. It is this feedback loop that ultimately mediates the intrinsic role of TORC1/2 in cellular homeostasis: TORC1/2 detects deviations from a steady-state condition and by means of these feedback loops returns the cell to its homeostatic situation. We propose to systematically identify the TORC1/2 homeostatic signalling loops. Subsequent characterization will focus on the signalling networks controlling intermediary metabolism. Our ultimate goal is to comprehensively unravel the TORC1/2-dependent metabolic networks composed of regulatory feedback loops which will reveal the fundamental role of the TOR Complexes as molecular devices to achieve cellular homeostasis.'