NLR-STRUCTURE

Drug Discovery Initiative for the Treatment of Chronic Inflammatory Disease

Coordinatore	ASTON UNIVERSITY    more  Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET contact info Titolo: Prof. Nome: Roslyn Cognome: Bill Email: send email Telefono: +44 121 204 4274
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	154˙617 €
EC contributo	154˙617 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IIF
Funding Scheme	MC-IIF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-05-02   -   2015-05-01

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ASTON UNIVERSITY  Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET contact info Titolo: Prof. Nome: Roslyn Cognome: Bill Email: send email Telefono: +44 121 204 4274	UK (BIRMINGHAM)	coordinator	154˙617.60

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 Obiettivo del progetto (Objective)

'Chronic inflammation is central to disease progression and organ failure in the majority of common human diseases, including cardiovascular disease, inflammatory bowel disease, chronic kidney & liver disease, gout, asthma, arthritis and cancer. Together, these chronic conditions contribute substantially to morbidity and mortality and generate a profound socioeconomic burden. The NLRP-STRUCTURE project will pave the way for the development of first-in-class drugs that can target select NLRP inflammasome members within different diseases endemic to the EU population. World-leading protein expression technologies will be integrated with unique chemoproteomic drug discovery platforms with the purpose of achieving rationalized drug development. Structure-activity guided medicinal chemistry will allow the team to propose drug leads that can be used in the synthesis of a new generation of small molecule pharmaceuticals for chronic inflammatory disease management. The project can provide data and information sourced from health databases, basic and translational research, and in-house analysis by a network of academic/clinical/industry experts. Thus, NLRP-STRUCTURE has the potential to develop new diagnostic, prognostic and therapeutic strategies that will improve the clinical care of patients across a wide range of chronic and debilitating disease. The entry of pipeline molecules will boost the anti-inflammatory therapeutics industry, thereby bringing about further economic stimulation to the therapeutics market in the coming years. The research objectives of NLRP-STRUCTURE will position the Host and partners in positions as world leader, as an acknowledged centre of global excellence in NLRP therapeutic discovery. Integral to the proposal is the development of patent landscapes and strategic partnerships that will play substantial roles in shaping the market in the future.'