ASCE

Aberrant Splicing of CFTR Exon 9

Coordinatore	Masarykova univerzita    more  Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 contact info Titolo: Dr. Nome: Veronika Cognome: Papouskova Email: send email Telefono: 420549000000
Nazionalità Coordinatore	Czech Republic [CZ]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2018-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Masarykova univerzita  Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 contact info Titolo: Dr. Nome: Veronika Cognome: Papouskova Email: send email Telefono: 420549000000	CZ (BRNO STRED)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease. Despite the importance of alternative splicing regulation our knowledge at the molecular level is still in its infancy hampering development of effective therapies. We plan to study the regulatory RNA-protein and protein-protein interaction networks leading to skipping of CFTR exon 9 associated with severe forms of cystic fibrosis. Structure determination of regulatory complexes by NMR spectroscopy in combination with biochemical and functional in vivo studies will be used to deepen our molecular understanding of the regulatory networks governing the proper assembly of mRNAs. With this, we want to reveal the molecular basis of aberrant CFTR exon 9 splicing and lay a rational, structure-function-based foundation for novel approaches to cure diseases.'