ANAEWARE

Monitoring awareness during anaesthesia – a multi-modal approach

Coordinatore	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE    more  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Mr. Nome: Shaun Cognome: Power Email: send email Telefono: +44 207 594 8773 Fax: +44 207 594 8609
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	299˙558 €
EC contributo	299˙558 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IEF
Funding Scheme	MC-IEF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-08-11   -   2016-08-10

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Mr. Nome: Shaun Cognome: Power Email: send email Telefono: +44 207 594 8773 Fax: +44 207 594 8609	UK (LONDON)	coordinator	299˙558.40

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 Obiettivo del progetto (Objective)

'Modern anesthesia is achieved through the administration of a 'chemical cocktail' of agents, each targeting a specific desirable effect (loss of awareness, analgesia, amnesia and immobility). Given that there are no strict dosages for these combinations of agents, the anesthetist follows a set of approximate dosage guidelines and adjusts these based on patient characteristics and past experience. However, administering an incorrect dosage could have serious complications: over-administration of anesthetics could result in cardiovascular depression, while under-administration in intraoperative awareness. The latter in particular could result to severe psychological consequences for the patient and economic consequences in the form of large insurance claims. Given that an estimated 234.2 million major surgical procedures are conducted annually worldwide, the seemingly small reported incidence of awareness (0.1-0.8%) corresponds to approximately 1,873,600 people. Despite the existence of commercially available devices that monitor anesthetic depth through the patient’s electrical brain activity (EEG), reliability and robustness issues stop them from becoming part of routine surgical practice. The project proposes a new direction in the field: the combination of various multi-modal signals to obtain a holistic view of anesthetic-induced changes. How is the body as a whole affected by this chemical 'cocktail'? What are the measurable effects of anesthesia on the relationships between different signals? The project will investigate such questions through the collection and study of multi-modal signals during surgery, and their applicability for wakefulness/anesthesia discrimination. Training in various research and complementary skills will be achieved through the multi-disciplinary nature of the project. Integration of the fellow in an environment with an impressive track record in cutting-edge biomedical research will provide structured long-term career development.'