INDIGO

Investigation of Novel biomarkers and Definition of the role of the microbiome In Graves’ Orbitopathy (INDIGO)

Coordinatore	CARDIFF UNIVERSITY    more  Organization address address: Newport Road 30-36 city: CARDIFF postcode: CF24 ODE contact info Titolo: Dr. Nome: Keith Cognome: Sexton Email: send email Telefono: +44 2 920 879288 Fax: +44 2 920 874189
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙192˙798 €
EC contributo	1˙192˙798 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-05-01   -   2018-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CARDIFF UNIVERSITY  Organization address address: Newport Road 30-36 city: CARDIFF postcode: CF24 ODE contact info Titolo: Dr. Nome: Keith Cognome: Sexton Email: send email Telefono: +44 2 920 879288 Fax: +44 2 920 874189	UK (CARDIFF)	coordinator	295˙392.47
2	UNIVERSITA DEGLI STUDI DI MILANO  Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 contact info Titolo: Prof. Nome: Anna Cognome: Spada Email: send email Telefono: 390250000000 Fax: 390250000000	IT (MILANO)	participant	315˙196.20
3	PARCO TECNOLOGICO PADANO S.R.L.  Organization address address: Via Einstein - Localita Cascina Codazza city: LODI postcode: 26900 contact info Titolo: Dr. Nome: Simona Cognome: Palermo Email: send email Telefono: +39 335 172 51 57 Fax: +390371 4662 217	IT (LODI)	participant	239˙209.86
4	CULTECH LTD  Organization address address: CHRISTCHURCH ROAD UNIT 2 city: PORT TALBOT WEST GLAMORGAN postcode: SA12 7BZ contact info Titolo: Dr. Nome: Susan Cognome: Plummer Email: send email Telefono: +44 1639 825100	UK (PORT TALBOT WEST GLAMORGAN)	participant	234˙886.73
5	UNIVERSITAETSKLINIKUM ESSEN  Organization address address: HUFELANDSTRASSE 55 city: ESSEN postcode: 45147 contact info Titolo: Mr. Nome: Sebastian Cognome: George Email: send email Telefono: 492017000000	DE (ESSEN)	participant	108˙113.28

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 Obiettivo del progetto (Objective)

'Graves' orbitopathy (GO), also known as thyroid eye disease, affects approximately 3 million people in Europe with an estimated socioeconomic burden of 6.4 billion euros per annum. GO is a complication of Graves' disease which is an autoimmune disease and the commonest cause of an overactive thyroid gland. The treatment of GO remains unsatisfactory and the majority of patients report long-term impairment of quality of life. To improve the outcomes of people with GO and thus reduce long-term illness and cost to society, research is needed to address the identification of risk factors, develop a better understanding of the pathophysiology of the disease, devise approaches for early diagnosis during the pre-clinical stage of the disease, and create novel and safe interventions. INDIGO will refine and optimise animal and in vitro models of Graves’ disease and GO, which are urgently required to facilitate the study of the pathogenesis of GO. INDIGO will address the identification of risk factors for the initiation and perpetuation of autoimmunity that causes disease, using the latest generation technologies to study variations in the microbiome in Graves and GO patients and controls. The interaction of the gut derived antigens, from micro-organisms and nutrients on the autoimmune response in both the animal model by probiotic and “contra-biotic” intervention. State of the art technology will be used to search for biomarkers that will identify patients that will progress to GO, during the preclinical phase of the disease when intervention is most likely to be successful. The successful completion of the project will be ensured by a partnership involving 2 SMEs, 3 academic institutions and the European Group on Graves' Orbitopathy, each contributing complementary expertise and technology, the project will involve 5 secondments and 3 recruitments that will facilitate the exchange of knowledge and training.'